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风疹病毒RA 27/3株对人淋巴细胞的体外作用。II. 与风疹血凝抑制抗体相关的特异性抗原刺激。

In vitro effects of Rubella virus, strain RA 27/3, on human lymphocytes. II. Specific antigen stimulation in relation to Rubella haemagglutination inhibition antibodies.

作者信息

Maller R, Sörén L

出版信息

Acta Pathol Microbiol Scand C. 1977 Aug;85C(4):307-13. doi: 10.1111/j.1699-0463.1977.tb03647.x.

DOI:10.1111/j.1699-0463.1977.tb03647.x
PMID:899801
Abstract

Investigation has been made of the specific in vitro stimulation of human lymphocytes by live or inactivated rubella virus of the strain RA 27/3. The thymidine incorporation of lymphocytes from blood donors with different serological immunity against rubella was measured following incubation with the viral antigens. UV-inactivated rubella virus caused a moderate degree of stimulation of lymphocytes from seropositive individuals. On the other hand, live rubella virus stimulated lymphocytes from donors with low titres of anti-rubella HI-antibodies but not lymphocytes from donors with high antibody titres. Possible explanations for this discrepancy are discussed.

摘要

已对RA 27/3株活风疹病毒或灭活风疹病毒对人淋巴细胞的特异性体外刺激进行了研究。在与病毒抗原孵育后，测量了具有不同风疹血清学免疫的献血者淋巴细胞的胸苷掺入情况。紫外线灭活的风疹病毒对血清阳性个体的淋巴细胞有中度刺激作用。另一方面，活风疹病毒刺激了抗风疹HI抗体滴度低的献血者的淋巴细胞，但未刺激抗体滴度高的献血者的淋巴细胞。讨论了这种差异的可能解释。

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