Buimovici-Klein E, Weiss K E, Cooper L Z
J Infect Dis. 1977 Mar;135(3):380-5. doi: 10.1093/infdis/135.3.380.
When stimulated with rubella virus irradiated with ultraviolet light, cultures of lymphocytes from individuals immune to rubella responded with production of 12-14 times more interferon than did cultures of lymphocytes from individuals susceptible to rubella. This property may be retained throughout life, since it was seen in individuals who had had rubella in their recent and remote pasts. Peak levels of interferon were detected six days after stimulation of lymphocytes with rubella virus antigen. In contrast, phytohemagglutinin induced production of interferon equally well in cultures of lymphocytes from persons immune and persons susceptible to rubella, with levels peaking three days after stimulation. Since there was a positive correlation among titers of hemagglutination-inhibiting antibody to rubella virus, incorporation of [14C]thymidine, and production of interferon after stimulation of lymphocyte cultures by rubella virus, interferon synthesis may be considered to be another measurable parameter of cell-mediated immunity in rubella.
当用紫外线照射的风疹病毒刺激时，对风疹免疫的个体的淋巴细胞培养物产生的干扰素比易患风疹的个体的淋巴细胞培养物多12 - 14倍。这种特性可能会终生保留，因为在近期和过去曾患过风疹的个体中都观察到了这一点。在用风疹病毒抗原刺激淋巴细胞六天后检测到干扰素的峰值水平。相比之下，植物血凝素在对风疹免疫和易患风疹的个体的淋巴细胞培养物中诱导产生干扰素的效果相同，刺激三天后水平达到峰值。由于风疹病毒血凝抑制抗体滴度、[14C]胸腺嘧啶掺入量以及风疹病毒刺激淋巴细胞培养物后干扰素产生之间存在正相关，因此干扰素合成可被视为风疹中细胞介导免疫的另一个可测量参数。
