Thouez J P, Latreille J, Rannou A, Ghadirian P
Unité de recherche en épidémiologie, Hôtel-Dieu de Montréal, Québec.
Sante. 1996 Sep-Oct;6(5):309-16.
This study describes the geographical variations in the incidence of, and mortality due to, the most frequent cancers in Quebec. They are breast, colon and tracheal, bronchial, and lung cancers in women and prostate, colon and trachea, bronchial and lung cancers in men. Data for the periods 1984 to 1986 and 1989 to 1991 for the whole of the Quebec Community Health Department are reviewed. A direct method of standardization, with the world population as the reference population, was used to allow comparison of geographical units. The ranking correlation method was used to test correlations for the various cancer sites. There were significant coefficients between the two periods only for lung cancer for both sexes, for both incidence and mortality. The spatial autocorrelation method was used to determine the presence or absence of a geographical configuration from the estimated rates. Moran I values were positive and significant for the two periods for lung cancer associated mortality and for the incidence of breast cancer. This implicates local factors (probably associated with lifestyle). The results for the incidence of lung cancer among men and women were similar for the period 1989 to 1991. The advantages and limitations of the methods used and also the data available are considered.
本研究描述了魁北克最常见癌症的发病率和死亡率的地理差异。这些癌症在女性中是乳腺癌、结肠癌以及气管、支气管和肺癌，在男性中是前列腺癌、结肠癌以及气管、支气管和肺癌。回顾了魁北克社区卫生部1984年至1986年以及1989年至1991年期间的数据。采用以世界人口作为参考人群的直接标准化方法，以便对各地理区域进行比较。使用等级相关法来检验不同癌症部位的相关性。仅在两个时期的男女肺癌发病率和死亡率方面存在显著系数。采用空间自相关法根据估计发病率来确定是否存在地理分布格局。在两个时期，与肺癌相关的死亡率以及乳腺癌发病率的莫兰指数值均为正且具有显著性。这意味着存在局部因素（可能与生活方式有关）。1989年至1991年期间，男性和女性肺癌发病率的结果相似。文中考虑了所使用方法以及现有数据的优缺点。
