Janne P, Carpentier Y, Willems G
Am J Dig Dis. 1977 Sep;22(9):808-12. doi: 10.1007/BF01694512.
The weight, the total crypt cell population, and the proliferation parameters of the colon were estimated in rats during a 4-week administration of a liquid elemental diet (Vivonex standard). Both mitotic and DNA synthesis activity were decreased (P less than 0.01) in the colonic mucosa during the administration of the diet. The weight of the colon was electively decreased (P less than 0.01) from the first week of the treatment. After four weeks, a 75% decrease in the cell population of mucosal glands was observed. This showed that considerable atrophy of the colonic mucosa occurred under the effect of feeding the elemental diet. This atrophy was probably mediated by a reduction in the proliferative activity of the stem cells in the mucosal glands.
在给大鼠喂食液体元素饮食（Vivonex标准）4周期间，对其结肠的重量、隐窝细胞总数和增殖参数进行了评估。在喂食期间，结肠黏膜中的有丝分裂和DNA合成活性均降低（P<0.01）。从治疗的第一周起，结肠重量选择性降低（P<0.01）。四周后，观察到黏膜腺细胞数量减少了75%。这表明在元素饮食喂养的影响下，结肠黏膜发生了明显萎缩。这种萎缩可能是由黏膜腺干细胞增殖活性降低介导的。
