Matsumoto T, Iida M, Kuroki F, Hizawa K, Koga H, Fujishima M
Second Department of Internal Medicine, Faculty of Medicine, Kyushu University, Fukuoka, Japan.
Gut. 1994 Aug;35(8):1058-63. doi: 10.1136/gut.35.8.1058.
The effects of dietary pretreatment on longitudinal ulcers of the intestine induced by indomethacin given intracolonically were investigated in rats. The rats were pretreated with either standard diet or liquid meals. Intracolonic indomethacin (24 mg/kg/day) given for two days produced longitudinal ulcers and small scattered ulcers in the small intestine in the control rats that were receiving standard pelleted formula. Three days pretreatment with one of two types of liquid meals, low residual diet (LRD) or elemental diet (ED), significantly reduced the incidence (3% in ED group and 0% in the LRD group) and the length of the longitudinal ulcers in the small intestine. The caecum was affected in each dietary pretreatment group (67% in controls, 80% in LRD group, and 69% in ED group). Colonic ulcers that were located in a longitudinal fashion were found in 42% of LRD group, while these ulcers were less frequently found in the ED group (13%) and controls (0%). Development of ulcers in the caecum and in the colon of rats in ED and LRD groups was more delayed than that of small intestinal ulcers of control rats. In another experiment, pretreatment by ED significantly increased colonic tissue leukotriene B4 concentration when compared with that of controls. These findings suggest that the site of experimental enteropathy induced by indomethacin given intracolonically can be modified by dietary pretreatment. This animal model can be available for investigating differences in the pathophysiology of enteropathy according to the site of involvement.
研究了饮食预处理对大鼠经结肠内给予吲哚美辛诱导的肠道纵向溃疡的影响。将大鼠用标准饮食或流食进行预处理。在接受标准颗粒饲料的对照大鼠中，连续两天给予结肠内吲哚美辛（24mg/kg/天）会在小肠中产生纵向溃疡和散在的小溃疡。用两种流食之一，即低残留饮食（LRD）或要素饮食（ED）进行三天预处理，可显著降低纵向溃疡的发生率（ED组为3%，LRD组为0%）和小肠中纵向溃疡的长度。每个饮食预处理组的盲肠均受到影响（对照组为67%，LRD组为80%，ED组为69%）。LRD组中42%的大鼠出现纵向分布的结肠溃疡，而ED组（13%）和对照组（0%）中这些溃疡的发生率较低。ED组和LRD组大鼠盲肠和结肠溃疡的发生比对照大鼠小肠溃疡的发生更延迟。在另一项实验中，与对照组相比，ED预处理显著提高了结肠组织白三烯B4的浓度。这些发现表明，经结肠内给予吲哚美辛诱导的实验性肠病部位可通过饮食预处理进行改变。该动物模型可用于研究根据受累部位不同的肠病病理生理学差异。
