Peter M G, Wollenberger U
Institut für Organische Chemie und Strukturanalytik, Universität Potsdam, Germany.
EXS. 1997;80:63-82. doi: 10.1007/978-3-0348-9043-4_5.
Phenolic compounds are widely distributed in nature. Enzymes which catalyze their oxidation are monophenol monooxygenases, such as tyrosinases and laccases, and peroxidases. Their metabolic role includes the decomposition of natural complex aromatic polymers as well as polymerization of the oxidation products and the degradation of xenobiotics. Their catalytic properties and broad availability gained impact on the development of biosenors for both environmentally important pollutants and clinically relevant metabolites. Mechanisms for the phenol-oxidizine enzymes tyrosinases, laccases, and peroxidases are reviewed and some examples for their use in the construction of phenol selective biosenors are given.
酚类化合物在自然界中广泛分布。催化其氧化的酶包括单酚单加氧酶，如酪氨酸酶和漆酶，以及过氧化物酶。它们的代谢作用包括天然复杂芳香聚合物的分解、氧化产物的聚合以及异生物质的降解。它们的催化特性和广泛可用性对用于环境重要污染物和临床相关代谢物的生物传感器的开发产生了影响。本文综述了酚氧化酶酪氨酸酶、漆酶和过氧化物酶的作用机制，并给出了它们在构建酚选择性生物传感器中的一些应用实例。
