Mackiewicz A
Department of Cancer Immunology, University School of Medical Sciences, GreatPoland Cancer Center, Poznań, Poland.
Int Rev Cytol. 1997;170:225-300. doi: 10.1016/s0074-7696(08)61623-x.
Acute phase proteins (APP) are plasma proteins whose concentration and glycosylation alters in response to tissue injury, inflammation, or tumor growth. Significant interspecies and sex differences in APP response exist. APP are produced mainly by hepatocytes, and their synthesis and glycosylation are controlled by a network consisting of cytokines, their soluble receptors, and glucocorticoids. The major cytokines involved in these processes belong to a group of interleukin-6-type cytokines that act through the hematopoietin receptor complex on hepatocytes and JAK-STAT signal transduction pathway. Transformed cells (hepatoma) display significant differences in synthesis of APP, cytokine responsiveness, expression of cytokine-receptor subunits and signal-transduction machinery. The most striking variability relates to the glycosylation alterations induced by cytokines. However, transformed cells (hepatoma) form a basic model for studying and understanding mechanisms controlling the synthesis and glycosylation of APP. Furthermore, APP may be secreted by transformed (tumor) cells of various origins and may display a growth factor-like function in certain cancer types.
急性期蛋白（APP）是血浆蛋白，其浓度和糖基化会因组织损伤、炎症或肿瘤生长而改变。APP反应存在显著的种间和性别差异。APP主要由肝细胞产生，其合成和糖基化受细胞因子、可溶性受体和糖皮质激素组成的网络控制。参与这些过程的主要细胞因子属于一组白细胞介素-6型细胞因子，它们通过肝细胞上的造血受体复合物和JAK-STAT信号转导途径发挥作用。转化细胞（肝癌细胞）在APP合成、细胞因子反应性、细胞因子受体亚基表达和信号转导机制方面表现出显著差异。最显著的变异性与细胞因子诱导的糖基化改变有关。然而，转化细胞（肝癌细胞）构成了研究和理解控制APP合成和糖基化机制的基本模型。此外，APP可能由各种来源的转化（肿瘤）细胞分泌，并在某些癌症类型中表现出生长因子样功能。
