Martius P, Hüther R, Zilker T
Psychiatrische Abteilung, Technischen Universität, Klinikum Rechts der Isar, München.
Nervenarzt. 1996 May;67(5):418-21.
We report on a woman patient with organophosphate poisoning resulting from a psychotically motivated suicide attempt. After detoxification and during treatment with haloperidol and levomepromazine, she developed acute malignant neuroleptic syndrome (MNS) in which dyspnea requiring assisted ventilation was the main symptom. Discontinuation of the neuroleptics was enough to effect sufficient recovery. With this case report, we would first like to emphasize that MNS can evolve within a very short time into a severe and life-threatening situation requiring intensive medical care, and secondly to illustrate the implications of organophosphate poisoning and the consequent cholinesterase blocking far the differential diagnosis of MNS.
我们报告了一名女性患者，她因企图自杀而服用有机磷导致中毒。在解毒之后，以及使用氟哌啶醇和左美丙嗪治疗期间，她出现了急性恶性抗精神病综合征（MNS），其中需要辅助通气的呼吸困难是主要症状。停用抗精神病药物足以实现充分康复。通过本病例报告，我们首先想强调的是，MNS可在很短时间内演变成需要重症医疗护理的严重且危及生命的情况，其次是说明有机磷中毒及随之而来的胆碱酯酶阻断对MNS鉴别诊断的影响。
