Bento M J, Leal C, Duez N, Lopes C
Serviço de Epidemiologia, Instituto Português de Oncologia de Francisco Gentil, Centro Regional do Porto, Porto.
Acta Med Port. 1996 Apr-Jun;9(4-6):129-33.
Genetic, cultural and environmental factors are influences shared in familial breast cancer. The objective of this study was to evaluate the prevalence of familial breast cancer and its association with social and clinical characteristics of women. A hospital-based descriptive study was made, and 300 patients with the diagnosis of breast cancer, made in 1992, were investigated. 17,4% of the women had a history of familial breast cancer. The presence of a positive history for familial breast cancer was associated with high social level for post-menopausal women. Age at diagnosis was older for women whose affected relative was their sister, not their mother. The need for the continuing efforts of epidemiologists, pathologists and geneticists to recognize the explanatory model of the disease is emphasized.
遗传、文化和环境因素是家族性乳腺癌共有的影响因素。本研究的目的是评估家族性乳腺癌的患病率及其与女性社会和临床特征的关联。开展了一项基于医院的描述性研究，对1992年确诊的300例乳腺癌患者进行了调查。17.4%的女性有家族性乳腺癌病史。家族性乳腺癌阳性病史的存在与绝经后女性的高社会阶层相关。受影响亲属为姐妹而非母亲的女性，其诊断年龄更大。强调了流行病学家、病理学家和遗传学家需要继续努力以识别该疾病的解释模型。
