Shekleton M, Lopata M, Evanich M J, Lourenço R V
Am Rev Respir Dis. 1976 Aug;114(2):341-6. doi: 10.1164/arrd.1976.114.2.341.
In 7 normal subjects, mouth occlusion pressure was evaluated as an index of neural drive to the respiratory muscles during CO2 rebreathing, with and without the addition of 2 degrees of elastic loads. During control and loaded rebreathing, changes in both mouth occlusion pressure and ventilation were linearly related to changes in end-tidal PCO2. With elastic loading, the slope of occlusion pressure versus end-tidal PCO2 response consistently increased from control values in all subjects and was greater with the higher load in 6 of 7 subjects. The ventilatory response to elastic loading was variable and inconsistent owing to the variable increase in frequency of breathing, the tidal volume always being diminished. In normal subjects, both mouth occlusion pressure and ventilation appeared to assess neural drive to the respiratory muscles in response to CO2 rebreathing; with elastic loading, only occlusion pressure continued to reflect neuromuscular output. This increased pressure response could have been mediated by neural reflex and/or intrinsic muscle mechanisms. The data suggest that mouth occlusion pressure may be a useful parameter for evaluating neuromuscular control mechanisms under conditions of increased lung elastance.
在7名正常受试者中，评估了口闭合压，以此作为在二氧化碳重复呼吸期间对呼吸肌神经驱动的指标，分别在添加和不添加2度弹性负荷的情况下进行评估。在对照和负荷重复呼吸期间，口闭合压和通气的变化均与呼气末PCO2的变化呈线性相关。施加弹性负荷时，所有受试者的口闭合压与呼气末PCO2反应的斜率均持续高于对照值，且在7名受试者中的6名中，负荷越高斜率越大。由于呼吸频率变化不定，弹性负荷下的通气反应多变且不一致，潮气量总是减小。在正常受试者中，口闭合压和通气似乎都可评估对二氧化碳重复呼吸的呼吸肌神经驱动；施加弹性负荷时，只有口闭合压继续反映神经肌肉输出。这种压力反应增加可能是由神经反射和/或内在肌肉机制介导的。数据表明，口闭合压可能是评估肺弹性增加情况下神经肌肉控制机制的有用参数。
