Heringlake S, Tillmann H L, Cordes-Temme P, Trautwein C, Hunsmann G, Manns M P
Department of Virology and Immunology, German Primate Center Göttingen, Germany.
J Hepatol. 1996 Dec;25(6):980-4. doi: 10.1016/s0168-8278(96)80306-0.
Recently, GBV-C and HGV-two isolates of the same new flavivirus-were identified in serum samples of patients with indeterminate hepatitis and posttransfusion hepatitis, respectively. The pathogenic relevance of these viruses is still uncertain. As viral infections are presumed to trigger autoimmune processes, we investigated GBV-C in autoimmune hepatitis as well as in cryptogenic hepatitis, and compared the prevalences to patients with chronic viral hepatitis and those of blood donors. We found only a slightly higher prevalence of the virus in cryptogenic (12%) and autoimmune hepatitis type I-III (6.7%, 10%, and 12.5%) compared to blood donors (4.7%). In contrast, patients with viral hepatitis B, C, and D were more frequently infected with GBV-C (16%, 20%, 36%). These results suggest that GBV-C is not a major cause for inducing autoimmunity and leading to autoimmune hepatitis. We analyzed the nucleic acid sequences of a representative number of GBV-C positive patients (24/42) and found a broad range of nucleotide similarity in the NS3 helicase region (74-100%) among the isolates and the prototype sequences. However, we could not identify a specific sequence, which would point to a certain strain or subtype of the virus associated with autoimmune or cryptogenic liver disease.
最近，在不明原因肝炎患者和输血后肝炎患者的血清样本中分别鉴定出GBV-C和HGV——两种属于同一新型黄病毒的毒株。这些病毒与致病的相关性仍不确定。由于推测病毒感染会引发自身免疫过程，我们对自身免疫性肝炎以及隐源性肝炎患者中的GBV-C进行了研究，并将其患病率与慢性病毒性肝炎患者和献血者的患病率进行了比较。我们发现，与献血者（4.7%）相比，GBV-C在隐源性肝炎（12%）以及I-III型自身免疫性肝炎（6.7%、10%和12.5%）中的患病率仅略高。相比之下，乙型、丙型和丁型病毒性肝炎患者感染GBV-C的频率更高（分别为16%、20%、36%）。这些结果表明，GBV-C并非诱导自身免疫和导致自身免疫性肝炎的主要原因。我们分析了相当数量GBV-C阳性患者（24/42）的核酸序列，发现在分离株与原型序列的NS3解旋酶区域中，核苷酸相似度范围很广（74-100%）。然而，我们未能鉴定出特定序列，该序列可以指向与自身免疫性或隐源性肝病相关的特定病毒株或亚型。
