Miller M A, Parkman H P, Urbain J L, Brown K L, Donahue D J, Knight L C, Maurer A H, Fisher R S
Department of Medicine, Temple University School of Medicine, Philadelphia, Pennsylvania 19140, USA.
Dig Dis Sci. 1997 Jan;42(1):10-8. doi: 10.1023/a:1018864400566.
The lactulose breath test (LBT) and gastroenterocolonic scintigraphy (GECS) can both be used to measure orocecal transit time (OCTT). The aims of this study were (1) to measure OCTT by LBT and GECS and (2) to determine whether lactulose alters orocecal transit.
Eight normal subjects underwent simultaneous breath hydrogen testing, GECS, and duodenal manometry while receiving either 10 g lactulose or placebo with a radiolabeled solid/liquid test meal during two studies. There was a good correlation between OCTT by LBT and GECS when performed simultaneously (r = 0.95; P < 0.001). OCTT by GECS with lactulose was significantly faster (P = 0.004) than by GECS without lactulose, despite no change in gastric emptying of liquids and slowing of gastric emptying of solids (P = 0.02). The postprandial duodenal motility index was greater with lactulose than with placebo (P = 0.031). This study demonstrates that LBT and GECS (without lactulose) are not equivalent measures of OCTT. The standard LBT accelerates OCTT and slows gastric emptying. Therefore, lactulose has a direct accelerating effect on small intestinal transit.
乳果糖呼气试验（LBT）和胃肠结肠闪烁显像（GECS）均可用于测量口盲传输时间（OCTT）。本研究的目的是：（1）通过LBT和GECS测量OCTT；（2）确定乳果糖是否改变口盲传输。
8名正常受试者在两项研究中接受10 g乳果糖或安慰剂以及放射性标记的固体/液体试验餐时，同时进行呼气氢检测、GECS和十二指肠测压。同时进行时，LBT和GECS测得的OCTT之间存在良好的相关性（r = 0.95；P < 0.001）。尽管液体胃排空无变化且固体胃排空减慢（P = 0.02），但使用乳果糖时GECS测得的OCTT显著快于未使用乳果糖时（P = 0.004）。乳果糖组餐后十二指肠动力指数高于安慰剂组（P = 0.031）。本研究表明，LBT和GECS（未使用乳果糖）并非OCTT的等效测量方法。标准LBT可加速OCTT并减慢胃排空。因此，乳果糖对小肠传输有直接加速作用。
