Lisheng W, Chutse W, Xuetao P, Li X, Jurong C, Fuchu H
Department of Experimental Hematology, Beijing Institute of Radiation Medicine, People's Republic of China.
Leuk Res. 1996 Nov-Dec;20(11-12):989-92. doi: 10.1016/s0145-2126(96)00051-3.
Dibutyl phthalate (DBP) showed preferential suppression of the growth of leukemic cells and could be used as a purging agent for autologous bone marrow transplantation in the treatment of leukemia. With in vitro exposure of leukemic cells to DBP, most characteristic changes in morphology of apoptosis could be observed by electron microscopy while DNA degraded in this fashion gave a 'ladder' pattern on DNA gel electrophoresis. The obtained results demonstrated that the purging effect of DBP on leukemic cells is mediated, at least in part, by the induction of apoptosis.
邻苯二甲酸二丁酯（DBP）对白血病细胞的生长有选择性抑制作用，可作为白血病治疗中自体骨髓移植的净化剂。白血病细胞在体外接触DBP后，通过电子显微镜可观察到凋亡形态的最典型变化，而以这种方式降解的DNA在DNA凝胶电泳上呈现出“梯状”模式。所得结果表明，DBP对白血病细胞的净化作用至少部分是由诱导凋亡介导的。
