Vértes Z, Környei J L, Kovács S, Vértes M
Institute of Physiology, University Medical School, Pécs, Hungary.
J Steroid Biochem Mol Biol. 1996 Oct;59(2):173-8. doi: 10.1016/s0960-0760(96)00101-x.
The present studies demonstrate, for the first time, that the rate of DNA synthesis in rat uterus of 21-32 days of age is inhibited by opioid peptides [D-Met2, Pro5]enkephalinamide. At around the time of vaginal opening (approximately 33 days) the opioids failed to act. High-affinity nuclear [3H]naloxone binding sites with linear Scatchard plots were detected in the uteri during the opioid-sensitive periods of DNA synthesis. Characteristics of these binding sites and the opioid sensitivity of uterine DNA synthesis are dependent on the age of the animals, the level of circulatory oestradiol and/or the maturity of the nuclear oestrogen receptor system.
目前的研究首次证明，阿片肽[D-蛋氨酸2，脯氨酸5]脑啡肽酰胺可抑制21至32日龄大鼠子宫中的DNA合成速率。在阴道开口前后（约33天），阿片类药物不起作用。在DNA合成的阿片类药物敏感时期，子宫中检测到具有线性Scatchard图的高亲和力核[3H]纳洛酮结合位点。这些结合位点的特征以及子宫DNA合成的阿片类药物敏感性取决于动物的年龄、循环雌二醇水平和/或核雌激素受体系统的成熟度。
