D（-）青霉胺对兔慢性实验性关节炎的作用。
Effect of D(-)penicillamine on chronic experimental arthritis in rabbits.
作者信息
Hunneyball I M, Stewart G A, Stanworth D R
出版信息
Ann Rheum Dis. 1977 Aug;36(4):378-80. doi: 10.1136/ard.36.4.378.
Abstract
Preliminary observations on the effect of D(-)penicillamine on chronic antigen-induced experimental arthritis in rabbits are reported. Daily oral administration of penicillamine, at a dose equivalent to that usually administered to rheumatoid arthritis patients, diminished the arthritis in 2 out of 3 animals as assessed by both measurement of joint circumference and histological examination.
摘要
本文报告了关于D（-）青霉胺对兔慢性抗原诱导实验性关节炎影响的初步观察结果。每日口服青霉胺，剂量等同于通常给予类风湿性关节炎患者的剂量，通过测量关节周长和组织学检查评估，3只动物中有2只的关节炎症状减轻。
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Effect of D(-)penicillamine on chronic experimental arthritis in rabbits.D（-）青霉胺对兔慢性实验性关节炎的作用。
Ann Rheum Dis. 1977 Aug;36(4):378-80. doi: 10.1136/ard.36.4.378.
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Effect of oral D-penicillamine treatment on experimental arthritis and associated immune responses in rabbits. III: Reduction of the monoarticular arthritis.口服D-青霉胺治疗对兔实验性关节炎及相关免疫反应的影响。III：单关节炎的减轻
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Pharmacological studies of antigen-induced arthritis in BALB/c mice. II. The effects of second-line antirheumatic drugs and cytotoxic agents on the histopathological changes.BALB/c小鼠抗原诱导性关节炎的药理学研究。II. 二线抗风湿药物和细胞毒药物对组织病理学变化的影响。
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引用本文的文献
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Effect of D-penicillamine Treatment on Certain Humoral Immunological Parameters in Clinical and Experimental Arthritis [Abstract].青霉胺治疗对临床及实验性关节炎某些体液免疫参数的影响[摘要]
Proc R Soc Med. 1977;70(Suppl 3):144-6. doi: 10.1177/00359157770700S344.
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In vitro monocyte-lymphocyte interaction influenced by d-penicillamine.青霉胺对体外单核细胞-淋巴细胞相互作用的影响
Clin Exp Immunol. 1982 Feb;47(2):474-80.
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Historical perspectives on penicillamine.青霉胺的历史视角
J R Coll Physicians Lond. 1980 Apr;14(2):130-6.
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A modified mouse air pouch model for evaluating the effects of compounds on granuloma induced cartilage degradation.一种改良的小鼠气袋模型，用于评估化合物对肉芽肿诱导的软骨降解的影响。
Br J Pharmacol. 1988 Mar;93(3):627-35. doi: 10.1111/j.1476-5381.1988.tb10320.x.
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Effect of oral D-penicillamine treatment on experimental arthritis and associated immune responses in rabbits. III: Reduction of the monoarticular arthritis.口服D-青霉胺治疗对兔实验性关节炎及相关免疫反应的影响。III：单关节炎的减轻
Ann Rheum Dis. 1979 Jun;38(3):271-8. doi: 10.1136/ard.38.3.271.
本文引用的文献
1
The production of arthritis in rabbits by an immunological reaction to fibrin.通过对纤维蛋白的免疫反应在兔子身上诱发关节炎。
Br J Exp Pathol. 1962 Aug;43(4):373-83.
2
Failure of oral D-penicillamine to modify adjuvant arthritis or immune response in the rat.口服D-青霉胺未能改善大鼠佐剂性关节炎或免疫反应。
Ann Rheum Dis. 1972 Nov;31(6):521. doi: 10.1136/ard.31.6.521.
3
Experimental immune synovitis in the rabbit. Relative roles of cell mediated and humoral immunity.兔实验性免疫性滑膜炎。细胞介导免疫和体液免疫的相对作用。
Arthritis Rheum. 1974 Nov-Dec;17(6):993-1005. doi: 10.1002/art.1780170612.
4
Production of a chronic arthritis with ovalbumin. Its retention in the rabbit knee joint.用卵清蛋白诱导慢性关节炎。其在兔膝关节中的留存情况。
Ann Rheum Dis. 1971 May;30(3):307-15. doi: 10.1136/ard.30.3.307.
5
Effect of D-penicillamine on lymphocyte function.D-青霉胺对淋巴细胞功能的影响。
Arzneimittelforschung. 1975 Apr;25(4):603-6.
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