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切除弗氏佐剂肉芽肿对实验性变态反应性关节炎后续发展的影响。

Effect of excising Freund's adjuvant granuloma on subsequent development of experimental allergic arthritis.

作者信息

Hirschowitz D, Fox A, Glynn L E

出版信息

Ann Rheum Dis. 1977 Aug;36(4):381-2. doi: 10.1136/ard.36.4.381.

Abstract

Rabbits were immunized with antigen in Freund's complete adjuvant. Several weeks later the granuloma which developed was excised one day before joint challenge with antigen. The subsequent development of experimental allergic arthritis (EAA) was not affected, which argues against the chronicity of the disease being maintained by continuous recruitment of mycobacterial debris to EAA joints.

摘要

用弗氏完全佐剂中的抗原免疫兔子。几周后,在关节用抗原激发前一天,将形成的肉芽肿切除。实验性变态反应性关节炎(EAA)的后续发展未受影响,这表明该疾病的慢性状态并非由分枝杆菌碎片持续募集到EAA关节所维持。

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