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切除弗氏佐剂肉芽肿对实验性变态反应性关节炎后续发展的影响。

Effect of excising Freund's adjuvant granuloma on subsequent development of experimental allergic arthritis.

作者信息

Hirschowitz D, Fox A, Glynn L E

出版信息

Ann Rheum Dis. 1977 Aug;36(4):381-2. doi: 10.1136/ard.36.4.381.

DOI:10.1136/ard.36.4.381
PMID:901038
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC1006703/
Abstract

Rabbits were immunized with antigen in Freund's complete adjuvant. Several weeks later the granuloma which developed was excised one day before joint challenge with antigen. The subsequent development of experimental allergic arthritis (EAA) was not affected, which argues against the chronicity of the disease being maintained by continuous recruitment of mycobacterial debris to EAA joints.

摘要

用弗氏完全佐剂中的抗原免疫兔子。几周后,在关节用抗原激发前一天,将形成的肉芽肿切除。实验性变态反应性关节炎(EAA)的后续发展未受影响,这表明该疾病的慢性状态并非由分枝杆菌碎片持续募集到EAA关节所维持。

相似文献

1
Effect of excising Freund's adjuvant granuloma on subsequent development of experimental allergic arthritis.切除弗氏佐剂肉芽肿对实验性变态反应性关节炎后续发展的影响。
Ann Rheum Dis. 1977 Aug;36(4):381-2. doi: 10.1136/ard.36.4.381.
2
The non-passage of mycobacteria from Freund's complete adjuvant granuloma depots to arthritic joints.分枝杆菌未从弗氏完全佐剂肉芽肿病灶转移至关节炎关节。
Br J Exp Pathol. 1975 Dec;56(6):537-43.
3
Induction of adjuvant arthritis in mice.小鼠佐剂性关节炎的诱导
Clin Exp Immunol. 1992 Dec;90(3):459-65. doi: 10.1111/j.1365-2249.1992.tb05868.x.
4
Recombinant mycobacterial HSP65 in combination with incomplete Freund's adjuvant induced rat arthritis comparable with that induced by complete Freund's adjuvant.重组分枝杆菌 HSP65 联合不完全弗氏佐剂诱导大鼠关节炎与完全弗氏佐剂诱导的关节炎相当。
J Immunol Methods. 2012 Dec 14;386(1-2):78-84. doi: 10.1016/j.jim.2012.09.002. Epub 2012 Sep 12.
5
Polyarthritis and the air pouch reaction: dissimilarity of adjuvant and collagen models.多关节炎与气囊肿反应:佐剂模型和胶原模型的差异
Immunopharmacology. 1988 Mar-Apr;15(2):123-30. doi: 10.1016/0162-3109(88)90059-8.
6
THE RESPONSE OF THE HISTIOCYTES AND MACROPHAGES IN THE LUNGS OF RABBITS INJECTED WITH FREUND'S ADJUVANT.注射弗氏佐剂的家兔肺部组织细胞和巨噬细胞的反应
Br J Exp Pathol. 1964 Oct;45(5):488-97.
7
[A model of polyarthritis in rats immunized with collagen].[用胶原蛋白免疫大鼠建立的多关节炎模型]
Reumatologia. 1983;21(1):5-13.
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Pathogenetic difference between collagen arthritis and adjuvant arthritis.胶原性关节炎与佐剂性关节炎之间的发病机制差异。
J Exp Med. 1984 May 1;159(5):1388-96. doi: 10.1084/jem.159.5.1388.
9
Sulforaphane Modulates Joint Inflammation in a Murine Model of Complete Freund's Adjuvant-Induced Mono-Arthritis.萝卜硫素调节完全弗氏佐剂诱导的单关节炎小鼠模型中的关节炎症。
Molecules. 2018 Apr 24;23(5):988. doi: 10.3390/molecules23050988.
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[Effect of vitamin D on the development and generalized spread of adjuvant arthritis in rats].
Patol Fiziol Eksp Ter. 1984 Jul-Aug(4):40-4.

本文引用的文献

1
Studies on adjuvant-induced polyarthritis in rats. I. Adjuvant composition, route of injection, and removal of depot site.大鼠佐剂诱导性多关节炎的研究。I. 佐剂成分、注射途径及注射部位的去除
Arthritis Rheum. 1962 Dec;5:557-64. doi: 10.1002/art.1780050604.
2
The production of arthritis in rabbits by an immunological reaction to fibrin.通过对纤维蛋白的免疫反应在兔子身上诱发关节炎。
Br J Exp Pathol. 1962 Aug;43(4):373-83.
3
Production of a chronic arthritis with ovalbumin. Its retention in the rabbit knee joint.用卵清蛋白诱导慢性关节炎。其在兔膝关节中的留存情况。
Ann Rheum Dis. 1971 May;30(3):307-15. doi: 10.1136/ard.30.3.307.
4
The non-passage of mycobacteria from Freund's complete adjuvant granuloma depots to arthritic joints.分枝杆菌未从弗氏完全佐剂肉芽肿病灶转移至关节炎关节。
Br J Exp Pathol. 1975 Dec;56(6):537-43.