Knight B, Katz D R, Isenberg D A, Ibrahim M A, Le Page S, Hutchings P, Schwartz R S, Cooke A
Department of Rheumatology Research, University College and Middlesex School of Medicine, London, UK.
Clin Exp Immunol. 1992 Dec;90(3):459-65. doi: 10.1111/j.1365-2249.1992.tb05868.x.
Adjuvant arthritis, induced by injections of Freund's complete adjuvant into the footpads of some rat strains, has been recognized as a useful animal model for many years. There has, however, been notable lack of success in reproducing this model in other species. We now describe the development of adjuvant arthritis in healthy strain mice approximately 2 months after injection of Freund's complete adjuvant. Although the clinical appearance of the mice and the joint histopathology closely resemble the adjuvant arthritis reported in the rat, we were unable to detect rheumatoid factor in sera from the affected animals. In parallel studies of T cell proliferation, affected animals responded to some mycobacterial antigens but not to the 65-kD heat shock protein of Mycobacterium tuberculosis, suggesting that some other epitope is important in the development of the disease.
多年来，通过向某些大鼠品系的足垫注射弗氏完全佐剂诱导的佐剂性关节炎，一直被认为是一种有用的动物模型。然而，在其他物种中复制该模型一直未取得显著成功。我们现在描述在健康品系小鼠中注射弗氏完全佐剂约2个月后佐剂性关节炎的发展情况。尽管小鼠的临床表现和关节组织病理学与大鼠中报道的佐剂性关节炎非常相似，但我们无法在患病动物的血清中检测到类风湿因子。在T细胞增殖的平行研究中，患病动物对一些分枝杆菌抗原有反应，但对结核分枝杆菌的65-kD热休克蛋白无反应，这表明其他一些表位在该疾病的发展中很重要。
