小鼠经抗CD3单克隆抗体治疗后可溶性肿瘤坏死因子受体的释放与肿瘤坏死因子-α的释放无关。
Soluble tumour necrosis factor receptor release after anti-CD3 monoclonal antibody treatment in mice is independent of tumour necrosis factor-alpha release.
作者信息
Vossen A C, Tibbe G J, Buurman W A, Benner R, Savelkoul H F
机构信息
Department of Immunology, Erasmus University, Rotterdam, The Netherlands.
出版信息
Eur Cytokine Netw. 1996 Dec;7(4):751-5.
The involvement of TNF-alpha in the release of soluble TNF receptors was assessed in mice, treated with anti-CD3 monoclonal antibodies. After treatment with three different anti-CD3 mAb, we simultaneously studied serum levels of TNF-alpha, soluble TNF receptor P55 and P75. All three anti-CD3 mAb triggered the release of both of the soluble TNF receptors, whereas only one of the anti-CD3 mAb triggered TNF-alpha release. These data demonstrate that in our model soluble TNF receptor release is independent of TNF-alpha release.
在使用抗CD3单克隆抗体治疗的小鼠中评估了肿瘤坏死因子-α（TNF-α）在可溶性TNF受体释放中的作用。在用三种不同的抗CD3单克隆抗体治疗后，我们同时研究了TNF-α、可溶性TNF受体P55和P75的血清水平。所有三种抗CD3单克隆抗体均触发了两种可溶性TNF受体的释放，而只有一种抗CD3单克隆抗体触发了TNF-α的释放。这些数据表明，在我们的模型中，可溶性TNF受体的释放独立于TNF-α的释放。
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