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The role of B7-1/B7-2:CD28/CLTA-4 pathways in the prevention of anergy, induction of productive immunity and down-regulation of the immune response.

作者信息

Boussiotis V A, Freeman G J, Gribben J G, Nadler L M

机构信息

Division of Hematologic Malignancies, Dana Farber Cancer Institute, Boston, MA 02115, USA.

出版信息

Immunol Rev. 1996 Oct;153:5-26. doi: 10.1111/j.1600-065x.1996.tb00918.x.

DOI:10.1111/j.1600-065x.1996.tb00918.x
PMID:9010717
Abstract
摘要

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The role of B7-1/B7-2:CD28/CLTA-4 pathways in the prevention of anergy, induction of productive immunity and down-regulation of the immune response.B7-1/B7-2:CD28/CLTA-4通路在预防无反应性、诱导有效免疫及下调免疫反应中的作用。
Immunol Rev. 1996 Oct;153:5-26. doi: 10.1111/j.1600-065x.1996.tb00918.x.
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CTLA-4 and T cell activation.细胞毒性T淋巴细胞相关抗原4与T细胞活化
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Blocking CD40 - CD154 and CD80/CD86 - CD28 interactions during primary allogeneic stimulation results in T cell anergy and high IL-10 production.在初次同种异体刺激过程中阻断CD40 - CD154和CD80/CD86 - CD28相互作用会导致T细胞无能并产生大量白细胞介素-10。
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