Christensson T, Hellström K, Wengle B
Arch Intern Med. 1977 Sep;137(9):1138-42. doi: 10.1001/archinte.137.9.1138.
Twenty patients being treated with thiazides were found among 95 subjects (21%) with hyercalcemia verified in repeated determinations in a health screening of 15,903 persons. There were 1,034 patients treated with thiazides in this total health screening. The prevalence of hypercalcemia in the patients treated with thiazides in this total health screening. The prevalence of hypercalcemia in the patients treated with thiazide (1.9%) was considerably higher than the prevalence of hypercalcemia found in the entire health-screened population (0.6%). The thiazide treatment was withdrawn in the 20 hypercalcemic subjects after an examination, and the patients were observed at intervals during a follow-up period of one year. The necks of 14 were explored during or after the follow-up period because of an initial serum calcium level greater than 3.0 mmole/liter or persistent hypercalcemia. Parathyroid adenomas were seen in all patients receiving surgery. Single adenomas predominated in surgical findings. The finding of the present high number of patients with primary hyperparathyroidism may be associated with elevated blood pressure resulting in thiazide treatment after detection.
在对15903人进行的健康筛查中，经反复测定确诊为高钙血症的95名受试者（21%）中有20名正在接受噻嗪类药物治疗。在这次全面健康筛查中，共有1034名患者接受了噻嗪类药物治疗。在这次全面健康筛查中，接受噻嗪类药物治疗的患者中高钙血症的患病率。接受噻嗪类药物治疗的患者中高钙血症的患病率（1.9%）显著高于在整个接受健康筛查人群中发现的高钙血症患病率（0.6%）。在检查后，这20名高钙血症患者停用了噻嗪类药物治疗，并在一年的随访期内定期对患者进行观察。由于初始血清钙水平大于3.0毫摩尔/升或持续性高钙血症，在随访期间或随访后对14名患者的颈部进行了探查。所有接受手术的患者均发现甲状旁腺腺瘤。手术结果中以单个腺瘤为主。目前发现大量原发性甲状旁腺功能亢进患者可能与血压升高有关，导致在检测后进行噻嗪类药物治疗。
