Bohr K C
Abteilung für Neurologisch-psychiatrische Funktionsdiagnostik, Krankenhauses Neuwittelsbach, München, Deutschland.
Wien Med Wochenschr. 1996;146(13-14):289-91.
In modern industry shift systems are important for optimal economic utilization of high-grade working plants. The implementation of shift systems, however, goes along with far-reaching social and health responsibilities of these organizations. This study plores, to what extent the intake of vitamin B12 before the beginning of a day shift has a stabilizing influence on the quality of sleep and the subjective estimate of the performance of the volunteers. The study was performed on 10 healthy, male staff members of a Tyrolean industrial plant with a mean age of 35 years, who work in a 12/12-h shift system as doormen. In a single blind placebo-verum-order all volunteers received first of all placebo for 2 weeks, then vitamin B12 (Methylcobal, 3 mg) for 3 weeks, at the morning before the day shift. By means of modified sleep-onset- and wake-up- records we studied the morning and evening state, the estimates of sleep time / -quality as well as the subjective judgement of the performance. The statements about periods of rest and activity were compared with the objective data of the wrist actimetry. Vitamin B12--concentrations in the serum were prepared for baseline and verum trials for each individual. In the whole group there were no significant differences in sleep-onset and wake-up ratings, nor in the subjective judgement of performance between placebo and verum. There were no significant particularities with respect to the weekdays or the time of day of activity. There was a tendency for the total sleep time in the verum trial to be shorter. The mean estimate of sleep quality under verum in significantly higher than under placebo in all volunteers.
在现代工业中，轮班制度对于高效利用先进工作设备以实现最佳经济效益至关重要。然而，实施轮班制度的同时，这些组织也肩负着广泛的社会责任和健康责任。本研究旨在探讨在白班开始前摄入维生素B12对志愿者睡眠质量和主观工作表现评估的稳定作用程度。该研究以10名健康的男性员工为对象，他们来自蒂罗尔州的一家工厂，平均年龄35岁，担任门卫，实行12小时轮班制。所有志愿者均采用单盲安慰剂-真药顺序给药，首先服用2周安慰剂，然后在白班开始前的早晨服用3周维生素B12（甲钴胺，3毫克）。通过改良的入睡和起床记录，我们研究了早晚状态、睡眠时间/质量评估以及工作表现的主观判断。将休息和活动时间段的记录与手腕活动记录仪的客观数据进行比较。为每位受试者准备了血清中维生素B12浓度的基线和真药试验数据。在整个实验组中，安慰剂组和真药组在入睡和起床评分以及工作表现的主观判断方面均无显著差异。在工作日或一天中的活动时间方面也没有显著特点。真药试验中的总睡眠时间有缩短的趋势。所有志愿者在服用真药时对睡眠质量的平均评估显著高于服用安慰剂时。
