[Development of senile plaques in the human brain].

In 100 persons, the development of senile plaques in 8 different parts of the brain was studied by means of Bielschowsky, Miagawa-Alexandrovskaja, phase contrast and morphometric methods. Appearance, within an unchanged brain tissue of a fine fibrillar structure, of a ball-shaped body (average diameter of 8.9 mcm) with a marked peripheral radiancy is believed by the author to be the first morphological stage of the senile plaque formation. Around this central focus, brain tissue necrosis separated from the normal brain tissue by a demarcation zone further develops. At final stages, desintegration and resolving of the central focus, and then of the whole senile plaque is observed.