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在媒体报道了使用第三代口服避孕药引发的不良血管事件后,挪威人工流产的数量增加了。

Increased number of induced abortions in Norway after media coverage of adverse vascular events from the use of third-generation oral contraceptives.

作者信息

Skjeldestad F E

机构信息

Department of Obstetrics and Gynecology, University Hospital of Trondheim, Norway.

出版信息

Contraception. 1997 Jan;55(1):11-4. doi: 10.1016/s0010-7824(96)00236-3.

DOI:10.1016/s0010-7824(96)00236-3
PMID:9013055
Abstract

After the press release in Lancet (October 18, 1995) of increased risks for adverse vascular events in users of pills containing desogestrel and gestodene the total sales of oral contraceptives dropped over a two-month period by 17%, while sales of the only desogestrel brand available (Marvelon) dropped by over 70% in Norway. From sales, we can estimate that more than 45,000 women either changed from Marvelon to a second or first-generation brand or stopped using OCs. In total, more than 25,000 women discontinued OC use in Norway during November and December of 1995. Abortion data from one Norwegian county, representing 6-7% of the Norwegian population, show no statistically significant changes in the total number of induced abortions from the first quarter of 1996 as compared with that of the first quarter in preceding years. However, abortion rates that had been steadily decreasing from 1992 through 1995 in women 24 years old or younger, were promptly interrupted by a significant 36% increase during the first quarter of 1996. Most of the additional cases were found among single, childless students. The observed increased abortion rate among younger women is most probably linked to changes in contraceptive use during the pill scare of the late October through December of 1995, during which time these women conceived.

摘要

1995年10月18日《柳叶刀》发布关于含去氧孕烯和孕二烯酮避孕药使用者发生不良血管事件风险增加的新闻稿后,口服避孕药的总销售额在两个月内下降了17%,而挪威唯一在售的去氧孕烯品牌(妈富隆)的销售额下降了70%以上。从销售额来看,我们估计有超过4.5万名女性要么从妈富隆换成了第二代或第一代品牌避孕药,要么停止使用口服避孕药。1995年11月和12月期间,挪威共有超过2.5万名女性停止使用口服避孕药。来自挪威一个占挪威人口6% - 7%的郡的堕胎数据显示,与前几年第一季度相比,1996年第一季度人工流产总数没有统计学上的显著变化。然而,1992年至1995年24岁及以下女性的堕胎率一直在稳步下降,在1996年第一季度却突然大幅上升了36%,这一趋势被迅速打断。新增的堕胎案例大多发生在单身、无子女的学生中。年轻女性中观察到的堕胎率上升很可能与1995年10月底至12月避孕药恐慌期间避孕方式的改变有关,这些女性就是在这段时间怀孕的。

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