Renooij W, Schmitz M G, van Gaal P J, Slappendel R J
Department of Surgery, University Hospital Utrecht, Faculty of Medicine, The Netherlands.
Eur J Clin Invest. 1996 Dec;26(12):1156-9. doi: 10.1046/j.1365-2362.1996.530611.x.
In dogs, hypertrophic gastritis, which resembles Ménétrier's disease in man, has been demonstrated to be part of a hereditary syndrome called familial stomatocytosis-hypertrophic gastritis. In addition to hypertrophic gastritis, affected dogs exhibit abnormal blood phospholipid composition. Phospholipids may play a role in maintaining gastric mucosal integrity, and this may be compromised in gastritis. The question arises whether the differences in blood phospholipids may result from a disorder that might also be revealed in the composition of gastric mucosal phospholipids. We analysed the phospholipid composition of gastric mucosa from four dogs with familial stomatocytosis-hypertrophic gastritis. The general phospholipid composition and the molecular composition of phosphatidylcholine from mucosal tissue in the corpus of the stomach where hypertrophic gastritis was evident were not different from that of the antrum, where the tissue was normal. These results do not corroborate a relation between the gastric mucosal phospholipid composition and hypertrophic gastritis.
在犬类中，肥厚性胃炎类似于人类的梅内特里耶病，已被证明是一种名为家族性口形细胞增多症-肥厚性胃炎的遗传综合征的一部分。除了肥厚性胃炎外，患病犬还表现出血液磷脂成分异常。磷脂可能在维持胃黏膜完整性方面发挥作用，而这在胃炎中可能会受到损害。问题在于血液磷脂的差异是否可能源于一种也可能在胃黏膜磷脂成分中显现的紊乱。我们分析了四只患有家族性口形细胞增多症-肥厚性胃炎的犬的胃黏膜磷脂成分。在肥厚性胃炎明显的胃体部黏膜组织中，总的磷脂成分以及磷脂酰胆碱的分子组成与组织正常的胃窦部并无差异。这些结果并未证实胃黏膜磷脂成分与肥厚性胃炎之间存在关联。
