Slappendel R J, van der Gaag I, van Nes J J, van den Ingh T S, Happé R P
Department of Clinical Sciences of Companion Animals, Faculty of Veterinary Medicine, University of Utrecht, The Netherlands.
Vet Q. 1991 Jan;13(1):30-40. doi: 10.1080/01652176.1991.9694282.
A newly recognised disease, which we have given the provisional name of familial stomatocytosis-hypertrophic gastritis (FSHG), is described in two families of dogs of the Drentse partrijshond breed. The affected dogs consisted of 3 females and 5 males, 3 to 19 (mean 9.5) months of age at admission. The main clinical problems were diarrhoea, icterus, and ataxia and paresis of the pelvic limbs. Laboratory evaluation revealed abnormal red cell shape (stomatocytosis), increased osmotic fragility, haemolytic anaemia, and increased liver enzymes and serum bilirubin. Gastroscopic and histopathologic examination of the gastric mucosa revealed hypertrophic gastritis resembling Ménétrier's disease in man. Histologic findings in the liver were suggestive of progressive liver disease. Cysts were found in the kidneys of the five oldest patients. Electroneurography in 2 dogs revealed polyneuropathy. In the parents of 2 patients (sister and brother), there were no clinical or laboratory abnormalities. An autosomal recessive hereditary defect of lipid metabolism is suspected.
在两个荷兰猎鹿犬品种的犬类家族中描述了一种新确认的疾病，我们暂时将其命名为家族性口形细胞增多症 - 肥厚性胃炎（FSHG）。受影响的犬只有3只雌性和5只雄性，入院时年龄在3至19个月（平均9.5个月）之间。主要临床问题是腹泻、黄疸以及骨盆肢体共济失调和轻瘫。实验室评估显示红细胞形状异常（口形细胞增多症）、渗透脆性增加、溶血性贫血以及肝酶和血清胆红素升高。胃黏膜的胃镜检查和组织病理学检查显示肥厚性胃炎，类似于人类的梅内特里耶病。肝脏的组织学发现提示进行性肝病。在五只年龄最大的病犬肾脏中发现了囊肿。对2只犬进行的神经电图检查显示有多发性神经病。在2例患者（兄妹）的父母中，没有临床或实验室异常。怀疑是脂质代谢的常染色体隐性遗传缺陷。
