Goodson H V, Valetti C, Kreis T E
Department of Cell Biology, Sciences III, University of Geneva, 30 quai Ernest Ansermet, 1211 Geneva 4, Switzerland.
Curr Opin Cell Biol. 1997 Feb;9(1):18-28. doi: 10.1016/s0955-0674(97)80147-0.
The cytoskeleton is essential for the proper function of many components of secretory and endocytic pathways, and the importance both of microtubule motors (kinesins and dyneins) and of actin motors (myosins) in these pathways is becoming apparent. Recent experiments have improved our understanding of which members of these motor protein families are involved in membrane traffic. Multiple motors are probably involved in the control of the morphology and dynamics of many membranes, and intriguing hints about how these motors are coordinated are appearing.
细胞骨架对于分泌和内吞途径中许多组分的正常功能至关重要,微管马达蛋白(驱动蛋白和动力蛋白)以及肌动蛋白马达蛋白(肌球蛋白)在这些途径中的重要性正日益显现。最近的实验增进了我们对这些马达蛋白家族中哪些成员参与膜转运的理解。多种马达蛋白可能参与了许多膜的形态和动力学控制,并且关于这些马达蛋白如何协同作用的有趣线索也正在浮现。