Kinoshita K, Yamamura M, Sugihara J
Pharmaceutical Development Research Laboratory, Tanabe Seiyaku Co., Ltd., Toda-shi, Saitama, Japan.
Biol Pharm Bull. 1997 Jan;20(1):86-7. doi: 10.1248/bpb.20.86.
Thyrotropin-releasing hormone (TRH) and its analog, TA-0910, ameliorate the ataxia of the mutant mouse, rolling mouse Nagoya, by metabolic normalization in the ventral tegmental field (VTF). We here investigated the distribution of cerebral TRH receptors in the rolling mouse to clarify the sites of action of these drugs. TRH receptors were widely distributed in multiple brain areas, including in the VTF and the cuneiform nucleus (CnF) which terminates in the VTF. These results suggest that TRH and TA-0910 directly activate the VTF by acting on TRH receptors in the VTF and indirectly activate it through the receptors in the CnF.
促甲状腺激素释放激素（TRH）及其类似物TA-0910，通过腹侧被盖区（VTF）的代谢正常化改善突变小鼠——滚动小鼠名古屋的共济失调。我们在此研究了滚动小鼠大脑中TRH受体的分布，以阐明这些药物的作用位点。TRH受体广泛分布于多个脑区，包括VTF和投射至VTF的楔形核（CnF）。这些结果表明，TRH和TA-0910通过作用于VTF中的TRH受体直接激活VTF，并通过CnF中的受体间接激活VTF。
