Nordström P, Gustavsson P, Edman G, Asberg M
Department of Clinical Neuroscience, Karolinska Institutet, Karolinska Hospital, Stockholm, Sweden.
Suicide Life Threat Behav. 1996 Winter;26(4):380-94.
The aim was to extend recent findings of suggested temperamental features in attempted suicide and to explore possible domains of vulnerability to suicide risk after attempted suicide. Fifty-four psychiatric inpatients hospitalized after a suicide attempt underwent lumbar puncture for analysis of CSF 5-HIAA concentration and also completed the Karolinska Scales of Personality (KSP) before discharge from the hospital. Suicide attempters scored high on Somatic Anxiety, Psychic Anxiety, and Muscular Tension, and low on Socialization, findings that support recent findings in suicide attempters followed up after an emergency room visit. Five patients committed early suicide, i.e., within 3 years, and the overall long-term suicide mortality after attempted suicide was 13%. There were significant correlations between survival time among early suicides and CSF 5-HIAA (r = .87; p = .054), and the following KSP scale t scores: Somatic Anxiety (r = -.96; p < .05), Impulsivity ( r = -.88; p < .05), and Socialization (r = 90; p < .05). KSP Socialization showed correlations with CSF 5-HIAA (r = .89; p = .046) among the early suicides. Features of temperamental vulnerability to suicide risk after attempted suicide might involve anxiety proneness, impulsivity, low socialization, and low CSF 5-HIAA.
本研究旨在扩展近期关于自杀未遂者气质特征的研究发现，并探索自杀未遂后自杀风险的潜在脆弱领域。54名自杀未遂后住院的精神科患者接受了腰椎穿刺以分析脑脊液5-羟吲哚乙酸（5-HIAA）浓度，并在出院前完成了卡罗林斯卡个性量表（KSP）。自杀未遂者在躯体焦虑、精神焦虑和肌肉紧张方面得分较高，在社交方面得分较低，这些发现支持了在急诊室就诊后对自杀未遂者进行随访的近期研究结果。5名患者在3年内早期自杀，自杀未遂后的总体长期自杀死亡率为13%。早期自杀者的生存时间与脑脊液5-HIAA之间存在显著相关性（r = 0.87；p = 0.054），以及以下KSP量表t得分：躯体焦虑（r = -0.96；p < 0.05）、冲动性（r = -0.88；p < 0.05）和社交（r = 0.90；p < 0.05）。在早期自杀者中，KSP社交与脑脊液5-HIAA存在相关性（r = 0.89；p = 0.046）。自杀未遂后自杀风险的气质脆弱特征可能包括焦虑倾向、冲动性、社交程度低和脑脊液5-HIAA水平低。
