Carroll D, Tramèr M, McQuay H, Nye B, Moore A
Nuffield Department of Anaesthetics, University of Oxford, Oxford Radcliffe Hospital, Headington.
Br J Anaesth. 1996 Dec;77(6):798-803. doi: 10.1093/bja/77.6.798.
We set out to examine the evidence for the importance of randomization of transcutaneous electrical nerve stimulation (TENS) in acute postoperative pain. Controlled studies were sought; randomization and analgesic and adverse effect outcomes were summarized. Forty-six reports were identified by searching strategies. Seventeen reports with 786 patients could be regarded unequivocally as randomized controlled trials (RCT) in acute postoperative pain. No meta-analysis was possible. In 15 of 17 RCT, we judged there to be no benefit of TENS compared with placebo. Of the 29 excluded trials, 19 had pain outcomes but were not RCT; in 17 of these 19 TENS studies, the authors concluded that TENS had a positive analgesic effect. No adverse effects were reported. Non-randomized studies overestimated treatment effects.
我们着手研究经皮电刺激神经疗法（TENS）随机化在急性术后疼痛中重要性的证据。我们寻找对照研究；总结随机化以及镇痛和不良反应结果。通过检索策略确定了46份报告。17份报告涉及786例患者，可明确视为急性术后疼痛的随机对照试验（RCT）。无法进行荟萃分析。在17项RCT中的15项中，我们判定与安慰剂相比，TENS没有益处。在29项排除的试验中，19项有疼痛结果但不是RCT；在这19项TENS研究中的17项中，作者得出结论认为TENS有积极的镇痛作用。未报告有不良反应。非随机研究高估了治疗效果。
