Wasir H S, Mahapatra R K, Bhatia M L, Roy S B, Sannerstedt R
Br Heart J. 1977 Aug;39(8):834-8. doi: 10.1136/hrt.39.8.834.
The antiarrhythmic effect of the cardioselective beta-adrenoceptor blocking agent metoprolol, given intravenously, was studied in 44 patients with various tachyarrhythmias, including patients with congestive heart failure and signs of digitalis intoxication. All patients with atrial tachycardia (12 cases) reverted to normal sinus rhythm. In 3 out of 18 patients with atrial fibrillation, sinus rhythm was restored, and in the others there was a significant reduction in ventricular rate. In 6 of 10 patients with ventricular ectopic beats, and 1 of 2 patients with ventricular tachycardia, the ectopic rhythm was abolished. The drug was well tolerated, without any significant changes in blood pressure, even by patients with signs of digitalis intoxication and varying degrees of pulmonary or peripheral circulatory congestion. Metoprolol is of clinical value for treatment of tachyarrhythmias, especially those of supraventricular origin.
对44例各种快速性心律失常患者（包括充血性心力衰竭患者和洋地黄中毒体征患者）进行了研究，观察静脉注射心脏选择性β肾上腺素能阻滞剂美托洛尔的抗心律失常作用。所有房性心动过速患者（12例）均恢复为正常窦性心律。18例心房颤动患者中有3例恢复窦性心律，其他患者心室率显著降低。10例室性早搏患者中有6例，2例室性心动过速患者中有1例异位心律被消除。即使是有洋地黄中毒体征以及不同程度肺循环或外周循环充血的患者，该药物耐受性良好，血压无任何显著变化。美托洛尔对治疗快速性心律失常具有临床价值，尤其是室上性起源的心律失常。
