质子去耦磷-31磁共振波谱在评估天然和功能良好的移植肾中的应用。

Proton-decoupled phosphorus-31 magnetic resonance spectroscopy in the evaluation of native and well-functioning transplanted kidneys.

作者信息

Vallée J P, Lazeyras F, Sostman H D, Smith S R, Butterly D W, Spritzer C E, Charles H C

机构信息

Department of Radiology, Duke Medical Center, Durham, NC, USA.

出版信息

Acad Radiol. 1996 Dec;3(12):1030-7. doi: 10.1016/s1076-6332(96)80040-7.

DOI:10.1016/s1076-6332(96)80040-7

PMID:9017019

Abstract

RATIONALE AND OBJECTIVES

To evaluate whether decoupling improves signal-to-noise ratio and frequency resolution of in vivo kidney spectra, and to compare native and well-functioning transplant kidneys.

METHODS

Proton decoupling in conjunction with three-dimensional chemical shift imaging (3D-CSI) in phosphorus-31 magnetic resonance (MR) spectroscopy was used with a spatial resolution of 64 cm3 and 17-minute acquisition time to compare native (n = 10) and well-functioning transplant (n = 9) kidneys.

RESULTS

Proton decoupling improved peak amplitudes by almost 30%, as well as chemical shift resolution of in vivo kidney spectra. No statistically significant differences in phosphometabolite ratios and renal spectra were observed between healthy volunteers and patients with nonrejecting transplants. The phosphodiester-phosphomonoester ratio was 3.02 +/- 0.88, phosphomonoester-inorganic phosphate ratio was 1.07 +/- 0.44, and inorganic phosphate-adenosine triphosphate ratio was 0.58 +/- 0.22 after correction for saturation effects.

CONCLUSION

Improved spectra of native and transplant kidneys can be obtained in vivo with MR spectroscopy by using a short acquisition time.

摘要

原理与目的

评估去耦是否能提高体内肾脏光谱的信噪比和频率分辨率，并比较正常肾脏和功能良好的移植肾脏。

方法

在磷-31磁共振（MR）波谱中，质子去耦与三维化学位移成像（3D-CSI）相结合，空间分辨率为64 cm³，采集时间为17分钟，用于比较正常肾脏（n = 10）和功能良好的移植肾脏（n = 9）。

结果

质子去耦使体内肾脏光谱的峰值幅度提高了近30%，同时提高了化学位移分辨率。在健康志愿者和未发生排斥反应的移植患者之间，未观察到磷酸代谢物比率和肾脏光谱有统计学显著差异。校正饱和效应后，磷酸二酯-磷酸单酯比率为3.02±0.88，磷酸单酯-无机磷酸比率为1.07±0.44，无机磷酸-三磷酸腺苷比率为0.58±0.22。