Suppr超能文献

人类生殖医学的前景——家畜育种实验技术的应用

Prospects for human reproductive medicine--applications of experimental techniques used in farm animal breeding.

作者信息

Michelmann H W, Rath D

机构信息

Arbeitsgruppe Reproduktionsmedizin, Frauenklinik der Universität, Göttingen, Germany.

出版信息

Andrologia. 1996;28 Suppl 1:93-5.

PMID:9017104
Abstract

Can assisted reproduction techniques performed in farm animal breeding be considered as future methods in human sterility treatment? The answer is no because, at the moment, the goals in human and animal reproduction are totally different. The methods that scientists are using or developing for farm animals are either without any therapeutic value for humans or they are forbidden by the German Embryo Protection Law. However, there are a few aspects which might be of value in the future of human assisted reproduction. The technique of in vitro maturation of immature follicles and oocytes, which is prerequisite in animal in vitro fertilization the female gamete pool after slaughter, might be used to obtain mature human oocytes from unstimulated cycles in women who do not respond to hormonal stimulation. Further more, it can be used in cancer patients to save their oocytes shortly before cancer treatment. Although still forbidden at the moment by the Embryo Protection Law, it is possible that the pre-implantation diagnosis of early embryos by the polymerase chain reaction technique after blastomere biopsy will become a valuable tool in preventing genome aberration in future.

摘要

家畜繁殖中使用的辅助生殖技术能否被视为未来人类不育治疗的方法?答案是否定的,因为目前人类和动物繁殖的目标完全不同。科学家们正在为家畜使用或开发的方法,要么对人类没有任何治疗价值,要么被德国胚胎保护法所禁止。然而,有几个方面可能在未来人类辅助生殖中具有价值。未成熟卵泡和卵母细胞的体外成熟技术是动物体外受精的前提条件,可利用该技术在屠宰后获取雌性配子库,这或许能用于从未经激素刺激而无反应的女性的未刺激周期中获取成熟的人类卵母细胞。此外,它还可用于癌症患者,在癌症治疗前不久保存其卵母细胞。尽管目前仍被胚胎保护法禁止,但在卵裂球活检后通过聚合酶链反应技术对早期胚胎进行植入前诊断,未来有可能成为预防基因组畸变的一项有价值的工具。

文献检索

告别复杂PubMed语法,用中文像聊天一样搜索,搜遍4000万医学文献。AI智能推荐,让科研检索更轻松。

立即免费搜索

文件翻译

保留排版,准确专业,支持PDF/Word/PPT等文件格式,支持 12+语言互译。

免费翻译文档

深度研究

AI帮你快速写综述,25分钟生成高质量综述,智能提取关键信息,辅助科研写作。

立即免费体验