Smiatacz T, Zielińska W
Clinic for Infectious Diseases, Medical Academy, Gdańsk, Poland.
Arch Immunol Ther Exp (Warsz). 1996;44(5-6):335-43.
Objective of the study was to determine whether there is any influence of hepatitis B virus (HBV) or hepatitis C virus (HCV) infection on CD4 count decline rate in HIV-infected individuals. Retrospective analysis of consecutive CD4 counts was conducted in 72 HIV-infected untreated individuals (including 57 intravenous drug addict (i.v.d.a.)) in relation to their serological markers of HBV and HCV infection and the history of i.v. substance abuse. Anti-HBc seropositive individuals had slower CD4 count decline rates compared to anti-HBc seronegative ones (-0.20%/month vs. -2.90%/month, Kruskal-Wallis H = 4.77, p = 0.029). Anti-HCV serostatus had no influence on CD4 count decline rates (-0.47%/month for anti-HCV seropositive persons vs. -0.61%/month for anti-HCV seronegative ones, p = 0.91). History of i.v. substance abuse did not affect the CD4 count decline rates too (-0.83 for i.v.d.a. vs +0.74 for non-i.v.d.a., p = 0.26). In our study HIV-infected individuals seropositive for anti-HBc tended to have substantially lower CD4 count decline rates compared to seronegative ones. Neither anti-HCV serostatus nor the history of i.v. substance abuse influenced the CD4 count decline rate. This observation arises question about the possible nature (molecular?, immune-based?) of potential mutual interactions between HIV and HBV infections.
本研究的目的是确定乙型肝炎病毒（HBV）或丙型肝炎病毒（HCV）感染是否对HIV感染者的CD4细胞计数下降率有任何影响。对72例未经治疗的HIV感染者（包括57例静脉吸毒者）的连续CD4细胞计数进行回顾性分析，分析其HBV和HCV感染的血清学标志物以及静脉吸毒史。抗-HBc血清阳性个体的CD4细胞计数下降率比抗-HBc血清阴性个体慢（-0.20%/月对-2.90%/月，Kruskal-Wallis H = 4.77，p = 0.029）。抗-HCV血清状态对CD4细胞计数下降率没有影响（抗-HCV血清阳性者为-0.47%/月，抗-HCV血清阴性者为-0.61%/月，p = 0.91）。静脉吸毒史也未影响CD4细胞计数下降率（静脉吸毒者为-0.83，非静脉吸毒者为+0.74，p = 0.26）。在我们的研究中，抗-HBc血清阳性的HIV感染者与血清阴性者相比，CD4细胞计数下降率往往显著更低。抗-HCV血清状态和静脉吸毒史均未影响CD4细胞计数下降率。这一观察结果引发了关于HIV与HBV感染之间潜在相互作用可能性质（分子层面？基于免疫？）的疑问。
