控制正痘病毒感染——詹纳革命性免疫接种200年后

Controlling orthopoxvirus infections--200 years after Jenner's revolutionary immunization.

作者信息

Niemiałtowski M G, Toka F N, Malicka E, Spohr de Faundez I, Schollenberger A

机构信息

Department of Microbiology and Immunology, Faculty of Veterinary Medicine, Warsaw Agricultural University, Poland.

出版信息

Arch Immunol Ther Exp (Warsz). 1996;44(5-6):373-8.

PMID:9017154

Abstract

An 11-year global WHO campaign for eradication of smallpox finished in October 1977 as the result of Edward Jenner's primary success in 1796, who for the first time applied human vaccination against variola virus (VARV). The 200th anniversary of this happening is a good occasion to summarize the current status of the knowledge about the role of B and T lymphocytes in the control of orthopoxvirus infections. This short review concentrates on general characteristics of orthopoxviruses and the immune response to infection, mainly by vaccinia virus (VV) and ectromelia virus (EV).

摘要

世界卫生组织开展的为期11年的全球消灭天花运动于1977年10月结束，这是爱德华·詹纳1796年取得初步成功的结果，他首次将人痘接种应用于天花病毒（VARV）。这一事件200周年之际，是总结目前关于B淋巴细胞和T淋巴细胞在控制正痘病毒感染中作用的知识现状的好时机。这篇简短的综述主要关注正痘病毒的一般特征以及对感染的免疫反应，主要是针对痘苗病毒（VV）和鼠痘病毒（EV）。