Tyc V L, Mulhern R K, Barclay D R, Smith B F, Bieberich A A
Division of Psychology, St. Jude Children's Research Hospital, Memphis, Tennessee 38101-0318, USA.
J Pediatr Psychol. 1997 Feb;22(1):45-58. doi: 10.1093/jpepsy/22.1.45.
Investigated the prevalence of anticipatory nausea and vomiting (ANV) among 59 pediatric cancer patients who had routinely received ondansetron (Zofran) antiemetic therapy and determined patient- and treatment-related factors associated with ANV. Of the sample, 59% indicated at least mild ANV symptoms, suggesting that a significant number of patients report ANV and are bothered by it, despite the use of Zofran. These children were compared to those reporting no ANV symptoms. Most ANV symptomatology was consistent with a traditional classical conditioning model although cognitive processes may also play a role. Children with greater expectations of severe postchemotherapy vomiting and those who were more distressed by nausea and vomiting were more likely to experience ANV symptoms. Implications for psychological and pharmacological treatments of ANV are discussed.
研究了59例常规接受昂丹司琼（枢复宁）止吐治疗的儿科癌症患者中预期性恶心和呕吐（ANV）的患病率，并确定了与ANV相关的患者及治疗相关因素。在该样本中，59%的患者表示至少有轻度ANV症状，这表明尽管使用了枢复宁，但仍有相当数量的患者报告有ANV并为此感到困扰。将这些儿童与未报告ANV症状的儿童进行了比较。大多数ANV症状与传统的经典条件反射模型一致，尽管认知过程可能也起作用。对化疗后严重呕吐期望更高以及因恶心和呕吐而更痛苦的儿童更有可能出现ANV症状。文中还讨论了ANV心理和药物治疗的意义。
