Valencia M E, Moreno V, Martínez P, González Lahoz J
Servicio de Enfermedades Infecciosas, Instituto de Salud Carlos III, Madrid.
An Med Interna. 1996 Nov;13(11):541-3.
Lymphomatous meningitis and lymphoma confined to the central nervous system are the most serious neurological diseases in patients with human immunodeficiency virus infection. The diagnosis is difficult and it is usually done with advanced systemic disease or when the chemotherapy is finished. During a ten month period, three patients with lymphomatous meningitis and HIV infection were diagnosed in an Infectious Diseases Unit. In one patient, was the initial clinical manifestation of Burkitt's lymphoma and in another, the diagnosis was concomitant with the neoplasm. In the last one, there was a meningeal recidiva afterwards he had received chemotherapy and, theoretically, cured his systemic lymphoma. Clinical, cytologic, immunologic and evolutive study of these three patients is done. It is discussed the meningeal prophylaxis usefulness with intrathecal chemotherapy.
淋巴瘤性脑膜炎和局限于中枢神经系统的淋巴瘤是人类免疫缺陷病毒感染患者中最严重的神经系统疾病。诊断困难,通常在出现晚期全身性疾病或化疗结束时才能做出诊断。在十个月的时间里,传染病科诊断出三名患有淋巴瘤性脑膜炎和艾滋病毒感染的患者。一名患者最初的临床表现为伯基特淋巴瘤,另一名患者的诊断与肿瘤同时出现。在最后一名患者中,他在接受化疗并理论上治愈了全身性淋巴瘤后出现了脑膜复发。对这三名患者进行了临床、细胞学、免疫学和病情演变研究。讨论了鞘内化疗在脑膜预防方面的作用。