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[人造血液的创制及生理学对实用医学的启示]

[The creation of artificial blood and the lessons of physiology for practical medicine].

作者信息

Ivanov K P

出版信息

Usp Fiziol Nauk. 1996 Oct-Dec;27(4):133-40.

PMID:9019920
Abstract

Nowadays the attempts to create the oxygen carrying blood substitutes ("artificial blood") based on the hemoglobin solution, have not met with success. This is accounted for by the fact that human blood hemoglobin efficiently fulfill the function of the gas transport in an organism only if it is included into an erythrocyte. The role of erythrocytes in the respiratory function of the blood is considered in this review. The newest methods are given of creating the "artificial blood" with the help of recombinant hemoglobin, the artificial erythrocytes and of obtaining the normal erythrocytes beyond an organism.

摘要

如今,试图基于血红蛋白溶液制造携氧血液替代品(“人造血液”)的尝试尚未成功。这是因为只有当人类血液血红蛋白被纳入红细胞时,它才能有效地在生物体内发挥气体运输功能。本文综述了红细胞在血液呼吸功能中的作用。介绍了借助重组血红蛋白、人造红细胞制造“人造血液”以及在生物体外获取正常红细胞的最新方法。

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