Robertson H A, Lam R W, Stewart J N, Yatham L N, Tam E M, Zis A P
Department of Psychiatry, University of British Columbia, Vancouver, Canada.
Acta Psychiatr Scand. 1996 Dec;94(6):421-7. doi: 10.1111/j.1600-0447.1996.tb09884.x.
In order to examine differences in the atypical symptoms of depression between unipolar and bipolar patients, we studied 109 depressed patients (79 unipolar and 30 bipolar subjects) diagnosed with DSM-IV criteria. Patients were assessed using the Atypical Depression Diagnostic Scale (ADDS), a semi-structured interview that rates mood reactivity and other atypical depressive symptoms. Although atypical depression was common in this sample (28% of cases with definite atypical depression), no differences were found between the unipolar and bipolar patients in either the atypical symptom profile or the prevalence of an atypical depression diagnosis. The interrelationships between the atypical symptoms were also examined using a hierarchical cluster analysis. A five-cluster solution maximized differences between groups, with results suggesting that atypical depression may be a heterogeneous diagnosis.
为了研究单相和双相情感障碍患者抑郁非典型症状的差异，我们对109名符合DSM-IV标准的抑郁症患者（79名单相情感障碍患者和30名双相情感障碍患者）进行了研究。使用非典型抑郁诊断量表（ADDS）对患者进行评估，这是一种半结构化访谈，用于评估情绪反应性和其他非典型抑郁症状。尽管非典型抑郁在该样本中很常见（28%的病例确诊为非典型抑郁），但在非典型症状特征或非典型抑郁诊断的患病率方面，单相和双相情感障碍患者之间均未发现差异。还使用分层聚类分析研究了非典型症状之间的相互关系。一个五类解决方案使组间差异最大化，结果表明非典型抑郁可能是一种异质性诊断。
