Boskey A L, Posner A S
Calcif Tissue Res. 1977 Oct 20;23(3):251-8. doi: 10.1007/BF02012794.
The calcium-phospholipid-phosphate (Ca-PL-PO4) complex isolated from young bone has been shown to initiate hydroxyapatite formation from a metastable calcium phosphate solution. The action of the complex was compared to that of the acidic phospholipids: phosphatidyl serine, phosphatidyl inositol and phosphatidic acid. These phospholipids first remove calcium, and a small amount of phosphate from the metastable solution forming a material similar to the complex isolated from bone, and then form hydroxyapatite. The rate of hydroxyapatite proliferation, once phosphatidyl serine and phosphatidyl inositol are converted to Ca-PL-PO4 complexes, is the same as the rate observed for comparable weights of the complex isolated from bone. It is suggested that the complex isolated from bone was formed in a manner similar to the complexes in our in vitro experiments. Finally, our evidence supports the possibility that a similar complex is responsible for the initial mineralization in matrix vesicles.
从幼骨中分离出的钙 - 磷脂 - 磷酸（Ca - PL - PO4）复合物已被证明可引发亚稳态磷酸钙溶液中羟基磷灰石的形成。将该复合物的作用与酸性磷脂（磷脂酰丝氨酸、磷脂酰肌醇和磷脂酸）的作用进行了比较。这些磷脂首先从亚稳态溶液中去除钙和少量磷酸盐，形成一种类似于从骨中分离出的复合物的物质，然后形成羟基磷灰石。一旦磷脂酰丝氨酸和磷脂酰肌醇转化为Ca - PL - PO4复合物，羟基磷灰石增殖的速率与从骨中分离出的同等重量的复合物所观察到的速率相同。有人提出，从骨中分离出的复合物是以类似于我们体外实验中复合物的方式形成的。最后，我们的证据支持了一种类似的复合物负责基质小泡中初始矿化的可能性。
