奥雷拉宁中毒：肾活检材料中真菌毒素的快速检测
Orellanine poisoning: rapid detection of the fungal toxin in renal biopsy material.
作者信息
Rohrmoser M, Kirchmair M, Feifel E, Valli A, Corradini R, Pohanka E, Rosenkranz A, Pöder R
机构信息
Institute of Microbiology, University of Innsbruck, Austria.
出版信息
J Toxicol Clin Toxicol. 1997;35(1):63-6. doi: 10.3109/15563659709001167.
BACKGROUND
Mushroom poisoning by some species of the Cortinarius (Agaricales) often lead to irreversible renal failure caused by the nephrotoxin orellanine. In 1994 and 1995, six poisoning outbreaks involving ten individuals in Northern Italy and in Austria were investigated.
METHODS
A total of 87 clinical samples (urine and blood samples including renal biopsy material of three patients) were examined for the presence of orellanine by thin layer chromatography.
RESULTS
Orellanine can be detected after a relatively long period following poisoning by performing a simple thin layer chromatography technique using small quantities of renal biopsy material. No toxin was found in urine or blood samples.
CONCLUSIONS
Orellanine is rapidly concentrated in the kidneys in a relatively soluble form and cannot be detected in urine, blood and dialysis fluids at the time when first symptoms appear.
背景
某些丝膜菌属（伞菌目）蘑菇中毒常导致由肾毒素奥来毒素引起的不可逆肾衰竭。1994年和1995年，对意大利北部和奥地利发生的涉及10人的6起中毒事件进行了调查。
方法
通过薄层色谱法对总共87份临床样本（尿液和血液样本，包括3名患者的肾活检材料）进行检测，以确定是否存在奥来毒素。
结果
通过使用少量肾活检材料进行简单的薄层色谱技术，在中毒后的较长一段时间后可以检测到奥来毒素。尿液或血液样本中未发现毒素。
结论
奥来毒素以相对可溶的形式迅速在肾脏中浓缩，在首次出现症状时无法在尿液、血液和透析液中检测到。
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