Brentegani L G, Bombonato K F, Carvalho T L
Department of Stomatology, Dental School of Ribeirão Preto, University of São Paulo, Brazil.
Biomaterials. 1997 Jan;18(2):137-40. doi: 10.1016/s0142-9612(96)00110-x.
A type III glass-ionomer cement (Vidrion F), currently used as fast-setting lining material and fissure sealant, was implanted into rat dental alveolus immediately after tooth extraction and its biocompatibility was analysed in terms of incorporation into alveolar bone in the wound healing process. Histological and histometric evaluation of trial areas adjacent to the implants showed that by week 1 the glass-ionomer granules were encircled by a conspicuous capsule surrounded by immature connective tissue. By week 3 the implants were surrounded by a less prominent fibrous capsule and most of the tested area was occupied by mature trabecular bone. By week 6 the fibrous capsule was thinner and the tested area was almost totally covered by bone, which was in close contact with the implanted material in several places. Quantitative data confirmed progressive new bone formation in parallel with a decrease in the percentage fraction of connective tissue in the trial areas around the implants. The results revealed that the tested material is biologically compatible, being progressively incorporated into alveolar bone in the wound healing process. The quantitative evaluation of alveolar wound healing around a glass-ionomer implant may provide an experimental model for future comparative studies carried out with other biomaterials.
一种III型玻璃离子水门汀（Vidrion F），目前用作快速凝固衬层材料和窝沟封闭剂，在拔牙后立即植入大鼠牙槽窝，并根据其在伤口愈合过程中与牙槽骨的结合情况分析其生物相容性。对植入物附近试验区的组织学和组织计量学评估表明，到第1周时，玻璃离子颗粒被一个明显的包膜包围，该包膜被不成熟的结缔组织环绕。到第3周时，植入物被一个不太明显的纤维包膜包围，大部分测试区域被成熟的小梁骨占据。到第6周时，纤维包膜变薄，测试区域几乎完全被骨覆盖，在几个地方骨与植入材料紧密接触。定量数据证实，随着植入物周围试验区结缔组织百分比的下降，新骨逐渐形成。结果表明，受试材料具有生物相容性，在伤口愈合过程中逐渐融入牙槽骨。对玻璃离子植入物周围牙槽伤口愈合的定量评估可能为未来与其他生物材料进行的比较研究提供一个实验模型。
