Carvalho T L, Teófilo J M, Araújo C A, Brentegani L G
Department of Stomatology, School of Dentistry of Ribeirño Preto, University of Sã Paulo, Brasil.
J Biomed Mater Res. 1997 Dec 15;37(4):449-52. doi: 10.1002/(sici)1097-4636(19971215)37:4<449::aid-jbm1>3.0.co;2-l.
The purpose of the present study was to determine whether granules of Ricinus communis polyurethane resin implanted immediately after tooth extraction interfere with the time course of alveolar wound healing in rats. Progressive bone neoformation in parallel to a decrease in the volume fraction of connective tissue was quantified by a histometric method 1, 2, 3, and 6 weeks after tooth extraction. In spite of the biocompatible nature, the presence of polyurethane resin granules in the cervical third led to a small (9-22%) but significant delay in bone formation in the middle and apical alveolar thirds from the second week on, as compared to controls.
本研究的目的是确定拔牙后立即植入的蓖麻聚氨酯树脂颗粒是否会干扰大鼠牙槽伤口愈合的时间进程。拔牙后1、2、3和6周，通过组织计量学方法对与结缔组织体积分数降低同时发生的渐进性骨新形成进行量化。尽管聚氨酯树脂颗粒具有生物相容性，但与对照组相比，从第二周开始，颈部三分之一处存在聚氨酯树脂颗粒导致中、根尖牙槽三分之一处的骨形成出现轻微（9%-22%）但显著的延迟。
