Georgopoulos S D, Mentis A F, Spiliadis C A, Tzouvelekis L S, Tzelepi E, Moshopoulos A, Skandalis N
Department of Gastroenterology, General Hospital of Athens, Greece.
Gut. 1996 Nov;39(5):634-8. doi: 10.1136/gut.39.5.634.
In recent studies, familial coinfection with the same Helicobacter pylori strains has been indicated, but more data are necessary to confirm intra-familial spread of the micro-organism.
The aim of this study was (a) to assess the frequency of H pylori infection in spouses of patients with duodenal ulcers and (b) to investigate the possibility of intraspousal typing of the respective strains.
Sixty four patients with duodenal ulcer and their spouses were included in the study.
The H pylori infection was confirmed after endoscopy by culture and histological examination of biopsy specimens, and CLO test. The isolates were compared on the basis of their rRNA gene patterns (ribopatterns) after digestion of chromosomal DNA by the restriction endonucleases HaeIII or HindIII.
Of the patients, 54 were found to be H pylori positive. Of the respective spouses, 42 (78%) were also H pylori positive. In contrast, only two out of 10 (20%) partners of H pylori negative patients were infected. Ribopatterns of H pylori strains derived from 18 patients and their spouses showed that in each of eight couples a single strain had colonised both partners, while in the remaining 10 couples each partner was colonised by a distinct H pylori strain.
These data suggest person to person transmission within couples or exposure to a common source of infection.
在最近的研究中，已表明存在感染相同幽门螺杆菌菌株的家族性合并感染，但需要更多数据来证实该微生物在家族内的传播情况。
本研究的目的是（a）评估十二指肠溃疡患者配偶中幽门螺杆菌感染的频率，以及（b）调查对各自菌株进行配偶间分型的可能性。
本研究纳入了64例十二指肠溃疡患者及其配偶。
在内镜检查后，通过活检标本的培养、组织学检查及CLO试验确认幽门螺杆菌感染。在用限制性内切酶HaeIII或HindIII消化染色体DNA后，根据分离株的rRNA基因模式（核糖分型）对其进行比较。
在这些患者中，发现54例幽门螺杆菌呈阳性。在各自的配偶中，42例（78%）也呈幽门螺杆菌阳性。相比之下，幽门螺杆菌阴性患者的10名配偶中只有2例（20%）被感染。来自18例患者及其配偶的幽门螺杆菌菌株的核糖分型显示，在8对夫妻中的每一对中，单一菌株定植于夫妻双方，而在其余10对夫妻中，夫妻双方各自被不同的幽门螺杆菌菌株定植。
这些数据表明夫妻之间存在人传人传播或暴露于共同感染源。
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