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英国癌症治疗中的随机对照研究:有改进空间吗?

Randomised comparative studies in the treatment of cancer in the United Kingdom: room for improvement?

作者信息

Tate H C, Rawlinson J B, Freedman L S

出版信息

Lancet. 1979 Sep 22;2(8143):623-5. doi: 10.1016/s0140-6736(79)91676-3.

DOI:10.1016/s0140-6736(79)91676-3
PMID:90280
Abstract

The basic details of randomised clinical studies in cancer treatment under way in the United Kingdom were ascertained in a postal survey. The cancers of major interest were those of lung, breast, colon and rectum, and lymphomas and leukaemias. In general, only a small proportion of cancer patients are entered into clinical studies; and most of the individual studies aim for a small number of patients, with patient entry over a long period.

摘要

通过一项邮寄调查确定了英国正在进行的癌症治疗随机临床研究的基本细节。主要关注的癌症类型为肺癌、乳腺癌、结肠癌、直肠癌、淋巴瘤和白血病。一般来说,只有一小部分癌症患者会参与临床研究;而且大多数单项研究的目标患者数量较少,患者入组时间较长。

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Randomised comparative studies in the treatment of cancer in the United Kingdom: room for improvement?英国癌症治疗中的随机对照研究:有改进空间吗?
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引用本文的文献

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As depressing as it was predictable? Lung cancer, clinical trials, and the Medical Research Council in postwar Britain.正如其可预测的那样令人沮丧?战后英国的肺癌、临床试验与医学研究理事会。
Bull Hist Med. 2007 Spring;81(1):312-34. doi: 10.1353/bhm.2007.0012.
2
Education and role modelling for clinical decisions with female cancer patients.针对女性癌症患者临床决策的教育与行为示范。
Health Expect. 2004 Dec;7(4):303-16. doi: 10.1111/j.1369-7625.2004.00294.x.
3
Bladder cancer.膀胱癌
Br Med J (Clin Res Ed). 1981 Mar 28;282(6269):1012-3.
4
Statistics and ethics in medical research. VIII-Improving the quality of statistics in medical journals.医学研究中的统计学与伦理学。八——提高医学期刊统计学质量
Br Med J (Clin Res Ed). 1981 Jan 3;282(6257):44-7. doi: 10.1136/bmj.282.6257.44.
5
Second laparotomy following 'curative' resection for colorectal cancer.结直肠癌“根治性”切除术后的二次剖腹手术。
Ann R Coll Surg Engl. 1983 Sep;65(5):314-5.
6
Who treats cancer?谁治疗癌症?
J R Coll Physicians Lond. 1987 Jan;21(1):61-6.
7
Cyclophosphamide and tamoxifen as adjuvant therapies in the management of breast cancer. CRC Adjuvant Breast Trial Working Party.环磷酰胺和他莫昔芬作为乳腺癌治疗的辅助疗法。CRC辅助性乳腺癌试验工作组。
Br J Cancer. 1988 Jun;57(6):604-7. doi: 10.1038/bjc.1988.137.
8
Improving the quality of data in clinical trials in cancer. COMPACT Steering Committee.
Br J Cancer. 1991 Mar;63(3):412-5. doi: 10.1038/bjc.1991.95.
9
The selection of cases for randomised trials: a registry survey of concurrent trial and non-trial patients. The British Stomach Cancer Group.随机试验病例的选择:对同期试验患者和非试验患者的登记调查。英国胃癌研究组
Br J Cancer. 1992 Nov;66(5):943-50. doi: 10.1038/bjc.1992.390.