环磷酰胺和他莫昔芬作为乳腺癌治疗的辅助疗法。CRC辅助性乳腺癌试验工作组。
Cyclophosphamide and tamoxifen as adjuvant therapies in the management of breast cancer. CRC Adjuvant Breast Trial Working Party.
出版信息
Br J Cancer. 1988 Jun;57(6):604-7. doi: 10.1038/bjc.1988.137.
Abstract
In 1980 the Cancer Research Campaign launched a multi-centre breast cancer trial; aimed at repeating the Scandinavian Chemotherapy Study Group's cyclophosphamide trial, and the NATO tamoxifen study; thereby further evaluating the role of these two adjuvant regimens in patients with early breast cancer. Two thousand two hundred and thirty women were randomized into this trial between 1980 and 1985 and preliminary analyses demonstrate a significant improvement in event-free survival for both regimens. Results from this study closely parallel the two trials it set out to repeat.
摘要
1980年，癌症研究运动发起了一项多中心乳腺癌试验；旨在重复斯堪的纳维亚化疗研究组的环磷酰胺试验以及北约的他莫昔芬研究；从而进一步评估这两种辅助治疗方案在早期乳腺癌患者中的作用。1980年至1985年间，2230名女性被随机纳入该试验，初步分析表明两种治疗方案的无事件生存率均有显著提高。这项研究的结果与它试图重复的两项试验结果非常相似。
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