Franc M, Cadiergues M C
Dermatology-Parasitology Unit, Ecole Vétérinaire de Toulouse, France.
Am J Vet Res. 1997 Feb;58(2):140-2.
To determine whether and for how long a single dose of a new injectable formulation of lufenuron would successfully control experimentally induced Ctenocephalides felis infestations in cats.
15 cats (3 groups of 5).
Each group of cats was housed in a separate room. Each cat was infested with 150 fleas, and flea counts were checked weekly. Once flea populations had stabilized, cats were treated with lufenuron at a dosage of 5 mg/kg of body weight, s.c. (group 1) or 10 mg/kg, s.c. (group 2). Group-3 cats were not treated. Flea counts were checked weekly for 18 weeks, and effectiveness was determined by comparing flea counts for treated cats with flea counts for control cats. Cats were reinfested with fleas during weeks 19, 26, 36, and 49, and flea counts were again determined weekly.
Effectiveness for both dosages of lufenuron was > 90% by 5 weeks after treatment, > 95% by 9 weeks after treatment, and > 98% by 13 weeks after treatment. Reinfestations performed during weeks 19 and 26 were well controlled (ie, > 90% reduction in flea counts, compared with control group) in both groups of cats treated with lufenuron. Reinfestations performed during week 36 were well controlled only in cats treated with lufenuron at the higher dosage. Reinfestations performed during week 49 were not controlled in either group of treated cats.
A single dose of the new injectable formulation of lufenuron should control flea populations in cats for up to 26 weeks, even among cats that are periodically reinfested with fleas.
确定单剂量新型注射用氟虫腈制剂能否成功控制实验诱导的猫栉首蚤感染以及能持续多久。
15只猫（3组，每组5只）。
每组猫饲养在单独的房间。每只猫感染150只跳蚤，每周检查跳蚤数量。一旦跳蚤数量稳定，猫用氟虫腈按5mg/kg体重皮下注射（第1组）或10mg/kg体重皮下注射（第2组）进行治疗。第3组猫不治疗。每周检查跳蚤数量，持续18周，通过比较治疗组猫和对照组猫的跳蚤数量来确定疗效。在第19、26、36和49周时猫再次感染跳蚤，并再次每周测定跳蚤数量。
两种剂量的氟虫腈在治疗后5周时疗效均>90%，治疗后9周时>95%，治疗后13周时>98%。在第19周和26周进行的再次感染在两组用氟虫腈治疗的猫中得到良好控制（即与对照组相比，跳蚤数量减少>90%）。在第36周进行的再次感染仅在用较高剂量氟虫腈治疗的猫中得到良好控制。在第49周进行的再次感染在两组治疗的猫中均未得到控制。
单剂量新型注射用氟虫腈制剂应能控制猫身上的跳蚤数量长达26周，即使是那些定期再次感染跳蚤的猫。
