Smith R D, Paul A J, Kitron U D, Philip J R, Barnett S, Piel M J, Ness R W, Evilsizer M
Department of Veterinary Pathobiology, College of Veterinary Medicine, University of Illinois, Urbana 61801, USA.
Am J Vet Res. 1996 Apr;57(4):502-4.
To evaluate the ability of lufenuron to control cat flea (Ctenocephalides felis felis) populations on dogs under conditions simulating a naturally infested home environment.
2 treatment and 2 control groups of dogs. Treated dogs received lufenuron in tablet form monthly, and controls received excipient. Dogs had unrestricted access to indoor (carpeted) and outdoor (grassy) environments in which self-propagating flea populations had been established.
17 adult female Beagles.
Dogs were monitored for 77 days after initial infestation with fleas and 70 days after initial treatment. Efficacy of the drug was calculated on the basis of absolute reduction in flea counts and as a percentage of control.
Lufenuron administration caused a statistically significant (P < 0.05) reduction in flea burdens in treated dogs, compared with controls. Initiation of treatment 7 days after infestation resulted in 75% control of F1-generation and 97% control of F2-generation fleas over a 70-day posttreatment period.
Lufenuron was highly effective in reducing flea populations on dogs. The time required for control will vary with the duration (generation time) of the flea reproductive cycle and, hence, the geographic area in which the product will be used. The experimental results are most relevant to use of the product for control of an existing flea population in the Midwest.
评估在模拟自然感染家庭环境的条件下，氯芬奴隆控制犬身上猫栉首蚤种群的能力。
将犬分为2个治疗组和2个对照组。治疗组犬每月口服氯芬奴隆片剂，对照组犬服用赋形剂。犬可自由出入已建立自我繁殖跳蚤种群的室内（铺有地毯）和室外（草地）环境。
17只成年雌性比格犬。
在首次感染跳蚤后对犬进行77天监测，在首次治疗后进行70天监测。根据跳蚤数量的绝对减少量以及作为对照的百分比来计算药物的疗效。
与对照组相比，给予氯芬奴隆使治疗组犬身上的跳蚤负担有统计学意义的显著减少（P < 0.05）。感染后7天开始治疗，在治疗后的70天内，对F1代跳蚤的控制率为75%，对F2代跳蚤的控制率为97%。
氯芬奴隆在减少犬身上的跳蚤种群方面非常有效。控制所需时间会因跳蚤繁殖周期的持续时间（世代时间）而有所不同，因此也会因产品使用的地理区域而有所不同。实验结果与该产品在中西部地区用于控制现有跳蚤种群最为相关。
