Jacobs D E, Hutchinson M J, Fox M T, Krieger K J
Department of Pathology and Infectious Diseases, Royal Veterinary College, University of London, North Mymms, Hatfield, Herts, United Kingdom.
Am J Vet Res. 1997 Nov;58(11):1260-2.
To compare the effect of monthly treatments with imidacloprid (an adulticide) or lufenuron (an insect development inhibitor) for protecting cats against Ctenocephalides felis felis in a simulated home environment.
3 matched groups of 4 cats each.
A self-propagating flea life cycle continuously exposing cats to 'natural' infestation was established in 3 pens. Small artificial infestations were later superimposed to mimic the effect of a cat roaming outdoors and acquiring extraneous fleas. One pen housed an untreated control group, and the other 2 pens housed cats treated every 28th day with an imidacloprid spot-on formulation or lufenuron suspension, respectively. Flea counts were performed at 14-day intervals for 112 days.
Flea numbers increased on control cats around day 42 when mean counts on cats in the imidacloprid and lufenuron groups decreased by 100 and 86.8 percent, respectively. Fleas were not found on any imidacloprid-treated cat, but lufenuron-treated cats were consistently parasitized.
Imidacloprid administered at monthly intervals maintained flea burdens below the limit of detection, whereas clinically important flea populations developed in the lufenuron treatment pen.
Results from this experimental model suggest that flea populations within a home may be controlled by carefully timed on-host treatments with potent long-acting insecticides such as imidacloprid.
在模拟家庭环境中比较每月使用吡虫啉（一种杀虫剂）或氟虫脲（一种昆虫发育抑制剂）治疗对保护猫免受猫栉首蚤指名亚种侵害的效果。
3组匹配的猫，每组4只。
在3个围栏中建立了一个自我繁殖的跳蚤生命周期，使猫持续暴露于“自然”感染环境。随后叠加了小规模的人工感染，以模拟猫在户外游荡并感染外来跳蚤的效果。一个围栏中饲养未治疗的对照组，另外两个围栏分别饲养每28天用吡虫啉滴剂制剂或氟虫脲悬浮液治疗的猫。在112天内每隔14天进行一次跳蚤计数。
在大约第42天时，对照组猫身上的跳蚤数量增加，而吡虫啉组和氟虫脲组猫身上的平均跳蚤计数分别下降了100%和86.8%。在任何接受吡虫啉治疗的猫身上都未发现跳蚤，但接受氟虫脲治疗的猫持续受到寄生。
每月施用吡虫啉可使跳蚤负担维持在检测限以下，而在氟虫脲治疗的围栏中出现了具有临床意义的跳蚤种群。
该实验模型的结果表明，家庭中的跳蚤种群可通过精心安排使用高效长效杀虫剂（如吡虫啉）进行宿主治疗来控制。
