估计DNA序列样本共同祖先的年龄。
Estimating the age of the common ancestor of a sample of DNA sequences.
作者信息
Fu Y X, Li W H
机构信息
Human Genetics Center, School of Public Health, University of Texas at Houston 77225, USA.
出版信息
Mol Biol Evol. 1997 Feb;14(2):195-9. doi: 10.1093/oxfordjournals.molbev.a025753.
We present a simple Monte Carlo method for estimating the age of the most recent common ancestor (MRCA) of a sample of DNA sequences. We show that Templeton's (1993) estimator of the age of the MRCA based on the maximum number of nucleotide differences between two sequences in a sample is inaccurate, and we demonstrate the new method by reanalyzing a sample of DNA sequences from human Y chromosomes and a sample of human Alu sequences.
我们提出了一种简单的蒙特卡罗方法，用于估计DNA序列样本的最近共同祖先（MRCA）的年龄。我们表明，Templeton（1993年）基于样本中两个序列之间核苷酸差异的最大数量对MRCA年龄的估计是不准确的，并且我们通过重新分析人类Y染色体的DNA序列样本和人类Alu序列样本，展示了这种新方法。
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