Araújo-Vilar D, Osifo E, Kirk M, García-Estévez D A, Cabezas-Cerrato J, Hockaday T D
Sheikh Rashid Diabetes Unit, Radcliffe Infirmary, Oxford, UK.
Metabolism. 1997 Feb;46(2):203-9. doi: 10.1016/s0026-0495(97)90303-6.
To establish the relative importance of insulin sensitivity and glucose effectiveness during exercise using Bergman's minimal model, 12 nontrained healthy subjects were studied at rest and during 95 minutes of moderate exercise (50% maximum oxygen consumption [VO2max]). Each subject underwent two frequently sampled intravenous glucose tolerance tests (FSIGTs) for 90 minutes, at rest (FSIGTr) and during exercise (FSIGTe). Plasma glucose, insulin, and C-peptide were determined. Insulin sensitivity (S(I)), glucose effectiveness at basal insulin (S(G)), insulin action [X(t)], and first-phase (phi1) and second-phase (phi2) beta-cell responsiveness to glucose were estimated using both minimal models of glucose disposal (MMg) and insulin kinetics (MMi). Glucose effectiveness at zero insulin (GEZI), glucose tolerance index (K(G)), and the area under the insulin curve (AUC(0-90)) were also calculated. Intravenous glucose tolerance improved significantly during physical exercise. During exercise, S(I) (FSIGTr v FSIGTe: 8.5 +/- 1.0 v 25.5 +/- 7.2 x 10(-5) x min(-1) [pmol x L(-1)]-1, P < .01), S(G) (0.195 +/- 0.03 v 0.283 +/- 0.03 x 10(-1) x min(-1), P < .05), and GEZI (0.190 +/- 0.03 v 0.269 +/- 0.04 x 10(-1) x min(-1), P < .05) increased; however, no changes in phi1 and phi2 were found. Despite a significant decrease in the insulin response to glucose (AUC0-90, 21,000 +/- 2,008 v 14,340 +/- 2,596 pmol x L(-1) x min, P < .01), insulin action [X(t)] was significantly higher during the FSIGTe. These results show that physical exercise improves mainly insulin sensitivity, and to a lesser degree, glucose effectiveness. During exercise, the insulin response to glucose was lower than at rest, but beta-cell responsiveness to glucose did not change.
为了使用伯格曼最小模型确定运动期间胰岛素敏感性和葡萄糖有效性的相对重要性，对12名未经训练的健康受试者在静息状态和95分钟的中等强度运动（50%最大耗氧量[VO2max]）期间进行了研究。每名受试者在静息状态（FSIGTr）和运动期间（FSIGTe）分别进行了两次90分钟的频繁采样静脉葡萄糖耐量试验（FSIGT）。测定血浆葡萄糖、胰岛素和C肽。使用葡萄糖处置最小模型（MMg）和胰岛素动力学最小模型（MMi）估算胰岛素敏感性（S(I)）、基础胰岛素水平下的葡萄糖有效性（S(G)）、胰岛素作用[X(t)]以及β细胞对葡萄糖的第一相（phi1）和第二相（phi2）反应性。还计算了零胰岛素水平下的葡萄糖有效性（GEZI）、葡萄糖耐量指数（K(G)）以及胰岛素曲线下面积（AUC(0 - 90)）。体育锻炼期间静脉葡萄糖耐量显著改善。运动期间，S(I)（FSIGTr与FSIGTe比较：8.5±1.0与25.5±7.2×10(-5)×min(-1)[pmol×L(-1)]-1，P <.01）、S(G)（0.195±0.03与0.283±0.03×10(-1)×min(-1)，P <.05）和GEZI（0.190±0.03与0.269±0.04×10(-1)×min(-1)，P <.05）升高；然而，未发现phi1和phi2有变化。尽管对葡萄糖的胰岛素反应显著降低（AUC0 - 90，21,000±2,008与14,340±2,596 pmol×L(-1)×min，P <.01），但在FSIGTe期间胰岛素作用[X(t)]显著更高。这些结果表明，体育锻炼主要改善胰岛素敏感性，对葡萄糖有效性的改善程度较小。运动期间，对葡萄糖的胰岛素反应低于静息状态，但β细胞对葡萄糖的反应性未改变。
